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Attitudes towards Vaccinations in a National Italian Cohort of Patients with Inflammatory Bowel Disease

Background: The vaccination status of patients with inflammatory bowel disease (IBD) should be investigated before starting any treatment, and patients should eventually be vaccinated against vaccine-preventable diseases (VPDs). Patients with IBD may have suboptimal vaccination rates. The aim of thi...

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Autores principales: Costantino, Andrea, Michelon, Marco, Noviello, Daniele, Macaluso, Fabio Salvatore, Leone, Salvo, Bonaccorso, Nicole, Costantino, Claudio, Vecchi, Maurizio, Caprioli, Flavio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611209/
https://www.ncbi.nlm.nih.gov/pubmed/37896993
http://dx.doi.org/10.3390/vaccines11101591
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author Costantino, Andrea
Michelon, Marco
Noviello, Daniele
Macaluso, Fabio Salvatore
Leone, Salvo
Bonaccorso, Nicole
Costantino, Claudio
Vecchi, Maurizio
Caprioli, Flavio
author_facet Costantino, Andrea
Michelon, Marco
Noviello, Daniele
Macaluso, Fabio Salvatore
Leone, Salvo
Bonaccorso, Nicole
Costantino, Claudio
Vecchi, Maurizio
Caprioli, Flavio
author_sort Costantino, Andrea
collection PubMed
description Background: The vaccination status of patients with inflammatory bowel disease (IBD) should be investigated before starting any treatment, and patients should eventually be vaccinated against vaccine-preventable diseases (VPDs). Patients with IBD may have suboptimal vaccination rates. The aim of this study was to evaluate the vaccination coverage, attitude towards vaccinations, and determinants among an Italian cohort of patients with IBD. Methods: AMICI, the Italian IBD patients’ association, sent an anonymous web-based questionnaire in February 2021. Previous vaccination status and patients’ attitudes towards vaccinations were recorded. We examined the factors influencing their attitudes using crude and adjusted odds ratios (adjORs) with 95% confidence intervals (CIs). Results: Among the 4039 patients invited, 1252 patients (including 729 women, median age 47.7 [37–58]) completed the questionnaire, with a response rate of 25.3%. Respondents declared being vaccinated against tetanus (74.1%), flu (67.7%; last season), MMR (43.3%), HBV (37.1%), pneumococcus (29.1%), meningitis (20%), HAV (16%), VZV (15.3%), and HPV (7.6%). Complete vaccination history was not remembered by 20.7% of the patients. One thousand one hundred and twelve (88.8%) expressed a positive attitude towards vaccination, 91 (7.3%) were indifferent, and 49 (3.9%) reported being opposed to vaccinations. The belief of a possible return of VPDs with a decline in vaccination coverage rates was the factor most strongly related to a positive attitude towards vaccinations (adjOR 5.67, 95% CI 3.45–9.30, p-value < 0.001). Conclusions: A low vaccination rate against some VPDs was found among a national cohort of patients with IBD, despite a generally positive attitude towards vaccinations.
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spelling pubmed-106112092023-10-28 Attitudes towards Vaccinations in a National Italian Cohort of Patients with Inflammatory Bowel Disease Costantino, Andrea Michelon, Marco Noviello, Daniele Macaluso, Fabio Salvatore Leone, Salvo Bonaccorso, Nicole Costantino, Claudio Vecchi, Maurizio Caprioli, Flavio Vaccines (Basel) Article Background: The vaccination status of patients with inflammatory bowel disease (IBD) should be investigated before starting any treatment, and patients should eventually be vaccinated against vaccine-preventable diseases (VPDs). Patients with IBD may have suboptimal vaccination rates. The aim of this study was to evaluate the vaccination coverage, attitude towards vaccinations, and determinants among an Italian cohort of patients with IBD. Methods: AMICI, the Italian IBD patients’ association, sent an anonymous web-based questionnaire in February 2021. Previous vaccination status and patients’ attitudes towards vaccinations were recorded. We examined the factors influencing their attitudes using crude and adjusted odds ratios (adjORs) with 95% confidence intervals (CIs). Results: Among the 4039 patients invited, 1252 patients (including 729 women, median age 47.7 [37–58]) completed the questionnaire, with a response rate of 25.3%. Respondents declared being vaccinated against tetanus (74.1%), flu (67.7%; last season), MMR (43.3%), HBV (37.1%), pneumococcus (29.1%), meningitis (20%), HAV (16%), VZV (15.3%), and HPV (7.6%). Complete vaccination history was not remembered by 20.7% of the patients. One thousand one hundred and twelve (88.8%) expressed a positive attitude towards vaccination, 91 (7.3%) were indifferent, and 49 (3.9%) reported being opposed to vaccinations. The belief of a possible return of VPDs with a decline in vaccination coverage rates was the factor most strongly related to a positive attitude towards vaccinations (adjOR 5.67, 95% CI 3.45–9.30, p-value < 0.001). Conclusions: A low vaccination rate against some VPDs was found among a national cohort of patients with IBD, despite a generally positive attitude towards vaccinations. MDPI 2023-10-13 /pmc/articles/PMC10611209/ /pubmed/37896993 http://dx.doi.org/10.3390/vaccines11101591 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Costantino, Andrea
Michelon, Marco
Noviello, Daniele
Macaluso, Fabio Salvatore
Leone, Salvo
Bonaccorso, Nicole
Costantino, Claudio
Vecchi, Maurizio
Caprioli, Flavio
Attitudes towards Vaccinations in a National Italian Cohort of Patients with Inflammatory Bowel Disease
title Attitudes towards Vaccinations in a National Italian Cohort of Patients with Inflammatory Bowel Disease
title_full Attitudes towards Vaccinations in a National Italian Cohort of Patients with Inflammatory Bowel Disease
title_fullStr Attitudes towards Vaccinations in a National Italian Cohort of Patients with Inflammatory Bowel Disease
title_full_unstemmed Attitudes towards Vaccinations in a National Italian Cohort of Patients with Inflammatory Bowel Disease
title_short Attitudes towards Vaccinations in a National Italian Cohort of Patients with Inflammatory Bowel Disease
title_sort attitudes towards vaccinations in a national italian cohort of patients with inflammatory bowel disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611209/
https://www.ncbi.nlm.nih.gov/pubmed/37896993
http://dx.doi.org/10.3390/vaccines11101591
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