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Nanovaccines to Combat Aeromonas hydrophila Infections in Warm-Water Aquaculture: Opportunities and Challenges

The application of nanotechnology in aquaculture for developing efficient vaccines has shown great potential in recent years. Nanovaccination, which involves encapsulating antigens of fish pathogens in various polymeric materials and nanoparticles, can afford protection to the antigens and a sustain...

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Autores principales: Harshitha, Mave, Nayak, Ashwath, Disha, Somanath, Akshath, Uchangi Satyaprasad, Dubey, Saurabh, Munang’andu, Hetron Mweemba, Chakraborty, Anirban, Karunasagar, Indrani, Maiti, Biswajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611256/
https://www.ncbi.nlm.nih.gov/pubmed/37896958
http://dx.doi.org/10.3390/vaccines11101555
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author Harshitha, Mave
Nayak, Ashwath
Disha, Somanath
Akshath, Uchangi Satyaprasad
Dubey, Saurabh
Munang’andu, Hetron Mweemba
Chakraborty, Anirban
Karunasagar, Indrani
Maiti, Biswajit
author_facet Harshitha, Mave
Nayak, Ashwath
Disha, Somanath
Akshath, Uchangi Satyaprasad
Dubey, Saurabh
Munang’andu, Hetron Mweemba
Chakraborty, Anirban
Karunasagar, Indrani
Maiti, Biswajit
author_sort Harshitha, Mave
collection PubMed
description The application of nanotechnology in aquaculture for developing efficient vaccines has shown great potential in recent years. Nanovaccination, which involves encapsulating antigens of fish pathogens in various polymeric materials and nanoparticles, can afford protection to the antigens and a sustained release of the molecule. Oral administration of nanoparticles would be a convenient and cost-effective method for delivering vaccines in aquaculture while eliminating the need for stressful, labour-intensive injectables. The small size of nanoparticles allows them to overcome the degradative digestive enzymes and help deliver antigens to the target site of the fish more effectively. This targeted-delivery approach would help trigger cellular and humoral immune responses more efficiently, thereby enhancing the protective efficacy of vaccines. This is particularly relevant for combating diseases caused by pathogens like Aeromonas hydrophila, a major fish pathogen responsible for significant morbidity and mortality in the aquaculture sector. While the use of nanoparticle-based vaccines in aquaculture has shown promise, concerns exist about the potential toxicity associated with certain types of nanoparticles. Some nanoparticles have been found to exhibit varying degrees of toxicity, and their safety profiles need to be thoroughly assessed before widespread application. The introduction of nanovaccines has opened new vistas for improving aquaculture healthcare, but must be evaluated for potential toxicity before aquaculture applications. Details of nanovaccines and their mode of action, with a focus on protecting fish from infections and outbreaks caused by the ubiquitous opportunistic pathogen A. hydrophila, are reviewed here.
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spelling pubmed-106112562023-10-28 Nanovaccines to Combat Aeromonas hydrophila Infections in Warm-Water Aquaculture: Opportunities and Challenges Harshitha, Mave Nayak, Ashwath Disha, Somanath Akshath, Uchangi Satyaprasad Dubey, Saurabh Munang’andu, Hetron Mweemba Chakraborty, Anirban Karunasagar, Indrani Maiti, Biswajit Vaccines (Basel) Review The application of nanotechnology in aquaculture for developing efficient vaccines has shown great potential in recent years. Nanovaccination, which involves encapsulating antigens of fish pathogens in various polymeric materials and nanoparticles, can afford protection to the antigens and a sustained release of the molecule. Oral administration of nanoparticles would be a convenient and cost-effective method for delivering vaccines in aquaculture while eliminating the need for stressful, labour-intensive injectables. The small size of nanoparticles allows them to overcome the degradative digestive enzymes and help deliver antigens to the target site of the fish more effectively. This targeted-delivery approach would help trigger cellular and humoral immune responses more efficiently, thereby enhancing the protective efficacy of vaccines. This is particularly relevant for combating diseases caused by pathogens like Aeromonas hydrophila, a major fish pathogen responsible for significant morbidity and mortality in the aquaculture sector. While the use of nanoparticle-based vaccines in aquaculture has shown promise, concerns exist about the potential toxicity associated with certain types of nanoparticles. Some nanoparticles have been found to exhibit varying degrees of toxicity, and their safety profiles need to be thoroughly assessed before widespread application. The introduction of nanovaccines has opened new vistas for improving aquaculture healthcare, but must be evaluated for potential toxicity before aquaculture applications. Details of nanovaccines and their mode of action, with a focus on protecting fish from infections and outbreaks caused by the ubiquitous opportunistic pathogen A. hydrophila, are reviewed here. MDPI 2023-10-01 /pmc/articles/PMC10611256/ /pubmed/37896958 http://dx.doi.org/10.3390/vaccines11101555 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Harshitha, Mave
Nayak, Ashwath
Disha, Somanath
Akshath, Uchangi Satyaprasad
Dubey, Saurabh
Munang’andu, Hetron Mweemba
Chakraborty, Anirban
Karunasagar, Indrani
Maiti, Biswajit
Nanovaccines to Combat Aeromonas hydrophila Infections in Warm-Water Aquaculture: Opportunities and Challenges
title Nanovaccines to Combat Aeromonas hydrophila Infections in Warm-Water Aquaculture: Opportunities and Challenges
title_full Nanovaccines to Combat Aeromonas hydrophila Infections in Warm-Water Aquaculture: Opportunities and Challenges
title_fullStr Nanovaccines to Combat Aeromonas hydrophila Infections in Warm-Water Aquaculture: Opportunities and Challenges
title_full_unstemmed Nanovaccines to Combat Aeromonas hydrophila Infections in Warm-Water Aquaculture: Opportunities and Challenges
title_short Nanovaccines to Combat Aeromonas hydrophila Infections in Warm-Water Aquaculture: Opportunities and Challenges
title_sort nanovaccines to combat aeromonas hydrophila infections in warm-water aquaculture: opportunities and challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611256/
https://www.ncbi.nlm.nih.gov/pubmed/37896958
http://dx.doi.org/10.3390/vaccines11101555
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