Cargando…

Weak Adoption and Performance of Hepatitis B Birth-Dose Vaccination Programs in Africa: Time to Consider Systems Complexity?—A Scoping Review

The persistent burden of chronic hepatitis B among ≤5-year-old children in Africa suggests missed opportunities for controlling mother-to-child transmission (MTCT) of the hepatitis B virus (HBV). This scoping review maps the evidence base on the risk of HBV MTCT, the status of HBV MTCT mitigation st...

Descripción completa

Detalles Bibliográficos
Autores principales: Solomon-Rakiep, Tasneem, Olivier, Jill, Amponsah-Dacosta, Edina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611266/
https://www.ncbi.nlm.nih.gov/pubmed/37888602
http://dx.doi.org/10.3390/tropicalmed8100474
_version_ 1785128451088318464
author Solomon-Rakiep, Tasneem
Olivier, Jill
Amponsah-Dacosta, Edina
author_facet Solomon-Rakiep, Tasneem
Olivier, Jill
Amponsah-Dacosta, Edina
author_sort Solomon-Rakiep, Tasneem
collection PubMed
description The persistent burden of chronic hepatitis B among ≤5-year-old children in Africa suggests missed opportunities for controlling mother-to-child transmission (MTCT) of the hepatitis B virus (HBV). This scoping review maps the evidence base on the risk of HBV MTCT, the status of HBV MTCT mitigation strategies including hepatitis B birth-dose vaccination, and the role of systems complexity on the suboptimal adoption and performance of hepatitis B birth-dose vaccination programs in Africa. Overall, 88 peer-reviewed and grey literature sources published between 2000–2022 were included in this review. The growing evidence base consistently argues for a heightened risk of HBV MTCT amidst the HIV co-epidemic in the region. Without universal HBV screening programs integrated within broader antenatal care services, current selective hepatitis B birth-dose vaccination is unlikely to effectively interrupt HBV MTCT. We underscore critical health systems-related barriers to universal adoption and optimal performance of hepatitis B birth-dose vaccination programs in the region. To better conceptualize the role of complexity and system-wide effects on the observed performance of the program, we propose an adapted systems-based logic model. Ultimately, exploring contextualized complex systems approaches to scaling-up universal hepatitis B birth-dose vaccination programs should form an integral part of the regional research agenda.
format Online
Article
Text
id pubmed-10611266
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106112662023-10-28 Weak Adoption and Performance of Hepatitis B Birth-Dose Vaccination Programs in Africa: Time to Consider Systems Complexity?—A Scoping Review Solomon-Rakiep, Tasneem Olivier, Jill Amponsah-Dacosta, Edina Trop Med Infect Dis Review The persistent burden of chronic hepatitis B among ≤5-year-old children in Africa suggests missed opportunities for controlling mother-to-child transmission (MTCT) of the hepatitis B virus (HBV). This scoping review maps the evidence base on the risk of HBV MTCT, the status of HBV MTCT mitigation strategies including hepatitis B birth-dose vaccination, and the role of systems complexity on the suboptimal adoption and performance of hepatitis B birth-dose vaccination programs in Africa. Overall, 88 peer-reviewed and grey literature sources published between 2000–2022 were included in this review. The growing evidence base consistently argues for a heightened risk of HBV MTCT amidst the HIV co-epidemic in the region. Without universal HBV screening programs integrated within broader antenatal care services, current selective hepatitis B birth-dose vaccination is unlikely to effectively interrupt HBV MTCT. We underscore critical health systems-related barriers to universal adoption and optimal performance of hepatitis B birth-dose vaccination programs in the region. To better conceptualize the role of complexity and system-wide effects on the observed performance of the program, we propose an adapted systems-based logic model. Ultimately, exploring contextualized complex systems approaches to scaling-up universal hepatitis B birth-dose vaccination programs should form an integral part of the regional research agenda. MDPI 2023-10-16 /pmc/articles/PMC10611266/ /pubmed/37888602 http://dx.doi.org/10.3390/tropicalmed8100474 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Solomon-Rakiep, Tasneem
Olivier, Jill
Amponsah-Dacosta, Edina
Weak Adoption and Performance of Hepatitis B Birth-Dose Vaccination Programs in Africa: Time to Consider Systems Complexity?—A Scoping Review
title Weak Adoption and Performance of Hepatitis B Birth-Dose Vaccination Programs in Africa: Time to Consider Systems Complexity?—A Scoping Review
title_full Weak Adoption and Performance of Hepatitis B Birth-Dose Vaccination Programs in Africa: Time to Consider Systems Complexity?—A Scoping Review
title_fullStr Weak Adoption and Performance of Hepatitis B Birth-Dose Vaccination Programs in Africa: Time to Consider Systems Complexity?—A Scoping Review
title_full_unstemmed Weak Adoption and Performance of Hepatitis B Birth-Dose Vaccination Programs in Africa: Time to Consider Systems Complexity?—A Scoping Review
title_short Weak Adoption and Performance of Hepatitis B Birth-Dose Vaccination Programs in Africa: Time to Consider Systems Complexity?—A Scoping Review
title_sort weak adoption and performance of hepatitis b birth-dose vaccination programs in africa: time to consider systems complexity?—a scoping review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611266/
https://www.ncbi.nlm.nih.gov/pubmed/37888602
http://dx.doi.org/10.3390/tropicalmed8100474
work_keys_str_mv AT solomonrakieptasneem weakadoptionandperformanceofhepatitisbbirthdosevaccinationprogramsinafricatimetoconsidersystemscomplexityascopingreview
AT olivierjill weakadoptionandperformanceofhepatitisbbirthdosevaccinationprogramsinafricatimetoconsidersystemscomplexityascopingreview
AT amponsahdacostaedina weakadoptionandperformanceofhepatitisbbirthdosevaccinationprogramsinafricatimetoconsidersystemscomplexityascopingreview