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The Effect of Acute Physical Exercise on Natural Killer Cells Populations and Cytokine Levels in Healthy Women

Physical exercise generates a systemic response in the immune system. It has been observed that cell populations respond to exercise stimuli, especially Natural Killer cells, whose number increase within minutes of starting physical exertion. This study aimed to evaluate the acute effect of moderate...

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Autores principales: Quintana-Mendias, Estefania, Rodríguez-Villalobos, Judith M., Gastelum-Arellanez, Argel, Cervantes, Natanael, Carrasco-Legleu, Claudia E., Espino-Solis, Gerardo Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611276/
https://www.ncbi.nlm.nih.gov/pubmed/37888516
http://dx.doi.org/10.3390/sports11100189
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author Quintana-Mendias, Estefania
Rodríguez-Villalobos, Judith M.
Gastelum-Arellanez, Argel
Cervantes, Natanael
Carrasco-Legleu, Claudia E.
Espino-Solis, Gerardo Pavel
author_facet Quintana-Mendias, Estefania
Rodríguez-Villalobos, Judith M.
Gastelum-Arellanez, Argel
Cervantes, Natanael
Carrasco-Legleu, Claudia E.
Espino-Solis, Gerardo Pavel
author_sort Quintana-Mendias, Estefania
collection PubMed
description Physical exercise generates a systemic response in the immune system. It has been observed that cell populations respond to exercise stimuli, especially Natural Killer cells, whose number increase within minutes of starting physical exertion. This study aimed to evaluate the acute effect of moderate- and high-intensity exercise on immunological markers in healthy women. As specific objectives, the percentages of CD3(-)CD56(+) Natural Killer total cells, CD56(bright)CD16(dim) effector subpopulation, CD56(dim)CD16(bright) cytotoxic subpopulation, NKG2A inhibition receptor, NKG2D activation receptor, and NKT cells were analyzed. In addition, the levels of the cytokines IL-1β, IL-6, IL-8, IL-10, IL-12p70, and TNF and the chemokines CCL5/RANTES, CXCL9/MIG, CCL2/MCP-1, and CXCL10/IP-10 were also analyzed. Natural Killer total cells showed an increase in their percentage in both exercise protocols (p = 0.001 for the moderate-intensity group and p = 0.023 for the high-intensity group); however, only in the high-intensity exercise session was there an increase in the CD56(dim)CD16(bright) cytotoxic subpopulation (p = 0.014), as well as a decrease in CD56(bright)CD16(dim) effector subpopulation (p = 0.001) and their NKG2A inhibition receptor (p = 0.043). An increase in IL-6 was observed after the high-intensity exercise session (p = 0.025). Conclusions. Physical exercise influences immunological markers and shows an acute response to moderate- or high-intensity exercise.
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spelling pubmed-106112762023-10-28 The Effect of Acute Physical Exercise on Natural Killer Cells Populations and Cytokine Levels in Healthy Women Quintana-Mendias, Estefania Rodríguez-Villalobos, Judith M. Gastelum-Arellanez, Argel Cervantes, Natanael Carrasco-Legleu, Claudia E. Espino-Solis, Gerardo Pavel Sports (Basel) Article Physical exercise generates a systemic response in the immune system. It has been observed that cell populations respond to exercise stimuli, especially Natural Killer cells, whose number increase within minutes of starting physical exertion. This study aimed to evaluate the acute effect of moderate- and high-intensity exercise on immunological markers in healthy women. As specific objectives, the percentages of CD3(-)CD56(+) Natural Killer total cells, CD56(bright)CD16(dim) effector subpopulation, CD56(dim)CD16(bright) cytotoxic subpopulation, NKG2A inhibition receptor, NKG2D activation receptor, and NKT cells were analyzed. In addition, the levels of the cytokines IL-1β, IL-6, IL-8, IL-10, IL-12p70, and TNF and the chemokines CCL5/RANTES, CXCL9/MIG, CCL2/MCP-1, and CXCL10/IP-10 were also analyzed. Natural Killer total cells showed an increase in their percentage in both exercise protocols (p = 0.001 for the moderate-intensity group and p = 0.023 for the high-intensity group); however, only in the high-intensity exercise session was there an increase in the CD56(dim)CD16(bright) cytotoxic subpopulation (p = 0.014), as well as a decrease in CD56(bright)CD16(dim) effector subpopulation (p = 0.001) and their NKG2A inhibition receptor (p = 0.043). An increase in IL-6 was observed after the high-intensity exercise session (p = 0.025). Conclusions. Physical exercise influences immunological markers and shows an acute response to moderate- or high-intensity exercise. MDPI 2023-10-02 /pmc/articles/PMC10611276/ /pubmed/37888516 http://dx.doi.org/10.3390/sports11100189 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Quintana-Mendias, Estefania
Rodríguez-Villalobos, Judith M.
Gastelum-Arellanez, Argel
Cervantes, Natanael
Carrasco-Legleu, Claudia E.
Espino-Solis, Gerardo Pavel
The Effect of Acute Physical Exercise on Natural Killer Cells Populations and Cytokine Levels in Healthy Women
title The Effect of Acute Physical Exercise on Natural Killer Cells Populations and Cytokine Levels in Healthy Women
title_full The Effect of Acute Physical Exercise on Natural Killer Cells Populations and Cytokine Levels in Healthy Women
title_fullStr The Effect of Acute Physical Exercise on Natural Killer Cells Populations and Cytokine Levels in Healthy Women
title_full_unstemmed The Effect of Acute Physical Exercise on Natural Killer Cells Populations and Cytokine Levels in Healthy Women
title_short The Effect of Acute Physical Exercise on Natural Killer Cells Populations and Cytokine Levels in Healthy Women
title_sort effect of acute physical exercise on natural killer cells populations and cytokine levels in healthy women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611276/
https://www.ncbi.nlm.nih.gov/pubmed/37888516
http://dx.doi.org/10.3390/sports11100189
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