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A Survey of Henipavirus Tropism—Our Current Understanding from a Species/Organ and Cellular Level

Henipaviruses are single-stranded RNA viruses that have been shown to be virulent in several species, including humans, pigs, horses, and rodents. Isolated nearly 30 years ago, these viruses have been shown to be of particular concern to public health, as at least two members (Nipah and Hendra virus...

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Detalles Bibliográficos
Autores principales: Diederich, Sandra, Babiuk, Shawn, Boshra, Hani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611353/
https://www.ncbi.nlm.nih.gov/pubmed/37896825
http://dx.doi.org/10.3390/v15102048
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author Diederich, Sandra
Babiuk, Shawn
Boshra, Hani
author_facet Diederich, Sandra
Babiuk, Shawn
Boshra, Hani
author_sort Diederich, Sandra
collection PubMed
description Henipaviruses are single-stranded RNA viruses that have been shown to be virulent in several species, including humans, pigs, horses, and rodents. Isolated nearly 30 years ago, these viruses have been shown to be of particular concern to public health, as at least two members (Nipah and Hendra viruses) are highly virulent, as well as zoonotic, and are thus classified as BSL4 pathogens. Although only 5 members of this genus have been isolated and characterized, metagenomics analysis using animal fluids and tissues has demonstrated the existence of other novel henipaviruses, suggesting a far greater degree of phylogenetic diversity than is currently known. Using a variety of molecular biology techniques, it has been shown that these viruses exhibit varying degrees of tropism on a species, organ/tissue, and cellular level. This review will attempt to provide a general overview of our current understanding of henipaviruses, with a particular emphasis on viral tropism.
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spelling pubmed-106113532023-10-28 A Survey of Henipavirus Tropism—Our Current Understanding from a Species/Organ and Cellular Level Diederich, Sandra Babiuk, Shawn Boshra, Hani Viruses Review Henipaviruses are single-stranded RNA viruses that have been shown to be virulent in several species, including humans, pigs, horses, and rodents. Isolated nearly 30 years ago, these viruses have been shown to be of particular concern to public health, as at least two members (Nipah and Hendra viruses) are highly virulent, as well as zoonotic, and are thus classified as BSL4 pathogens. Although only 5 members of this genus have been isolated and characterized, metagenomics analysis using animal fluids and tissues has demonstrated the existence of other novel henipaviruses, suggesting a far greater degree of phylogenetic diversity than is currently known. Using a variety of molecular biology techniques, it has been shown that these viruses exhibit varying degrees of tropism on a species, organ/tissue, and cellular level. This review will attempt to provide a general overview of our current understanding of henipaviruses, with a particular emphasis on viral tropism. MDPI 2023-10-04 /pmc/articles/PMC10611353/ /pubmed/37896825 http://dx.doi.org/10.3390/v15102048 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Diederich, Sandra
Babiuk, Shawn
Boshra, Hani
A Survey of Henipavirus Tropism—Our Current Understanding from a Species/Organ and Cellular Level
title A Survey of Henipavirus Tropism—Our Current Understanding from a Species/Organ and Cellular Level
title_full A Survey of Henipavirus Tropism—Our Current Understanding from a Species/Organ and Cellular Level
title_fullStr A Survey of Henipavirus Tropism—Our Current Understanding from a Species/Organ and Cellular Level
title_full_unstemmed A Survey of Henipavirus Tropism—Our Current Understanding from a Species/Organ and Cellular Level
title_short A Survey of Henipavirus Tropism—Our Current Understanding from a Species/Organ and Cellular Level
title_sort survey of henipavirus tropism—our current understanding from a species/organ and cellular level
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611353/
https://www.ncbi.nlm.nih.gov/pubmed/37896825
http://dx.doi.org/10.3390/v15102048
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