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Engineering Non-Human RNA Viruses for Cancer Therapy
Alongside the development and progress in cancer immunotherapy, research in oncolytic viruses (OVs) continues advancing novel treatment strategies to the clinic. With almost 50 clinical trials carried out over the last decade, the opportunities for intervention using OVs are expanding beyond the old...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611381/ https://www.ncbi.nlm.nih.gov/pubmed/37897020 http://dx.doi.org/10.3390/vaccines11101617 |
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author | Tur-Planells, Vicent García-Sastre, Adolfo Cuadrado-Castano, Sara Nistal-Villan, Estanislao |
author_facet | Tur-Planells, Vicent García-Sastre, Adolfo Cuadrado-Castano, Sara Nistal-Villan, Estanislao |
author_sort | Tur-Planells, Vicent |
collection | PubMed |
description | Alongside the development and progress in cancer immunotherapy, research in oncolytic viruses (OVs) continues advancing novel treatment strategies to the clinic. With almost 50 clinical trials carried out over the last decade, the opportunities for intervention using OVs are expanding beyond the old-fashioned concept of “lytic killers”, with promising breakthrough therapeutic strategies focused on leveraging the immunostimulatory potential of different viral platforms. This review presents an overview of non-human-adapted RNA viruses engineered for cancer therapy. Moreover, we describe the diverse strategies employed to manipulate the genomes of these viruses to optimize their therapeutic capabilities. By focusing on different aspects of this particular group of viruses, we describe the insights into the promising advancements in the field of virotherapy and its potential to revolutionize cancer treatment. |
format | Online Article Text |
id | pubmed-10611381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106113812023-10-28 Engineering Non-Human RNA Viruses for Cancer Therapy Tur-Planells, Vicent García-Sastre, Adolfo Cuadrado-Castano, Sara Nistal-Villan, Estanislao Vaccines (Basel) Review Alongside the development and progress in cancer immunotherapy, research in oncolytic viruses (OVs) continues advancing novel treatment strategies to the clinic. With almost 50 clinical trials carried out over the last decade, the opportunities for intervention using OVs are expanding beyond the old-fashioned concept of “lytic killers”, with promising breakthrough therapeutic strategies focused on leveraging the immunostimulatory potential of different viral platforms. This review presents an overview of non-human-adapted RNA viruses engineered for cancer therapy. Moreover, we describe the diverse strategies employed to manipulate the genomes of these viruses to optimize their therapeutic capabilities. By focusing on different aspects of this particular group of viruses, we describe the insights into the promising advancements in the field of virotherapy and its potential to revolutionize cancer treatment. MDPI 2023-10-20 /pmc/articles/PMC10611381/ /pubmed/37897020 http://dx.doi.org/10.3390/vaccines11101617 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tur-Planells, Vicent García-Sastre, Adolfo Cuadrado-Castano, Sara Nistal-Villan, Estanislao Engineering Non-Human RNA Viruses for Cancer Therapy |
title | Engineering Non-Human RNA Viruses for Cancer Therapy |
title_full | Engineering Non-Human RNA Viruses for Cancer Therapy |
title_fullStr | Engineering Non-Human RNA Viruses for Cancer Therapy |
title_full_unstemmed | Engineering Non-Human RNA Viruses for Cancer Therapy |
title_short | Engineering Non-Human RNA Viruses for Cancer Therapy |
title_sort | engineering non-human rna viruses for cancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611381/ https://www.ncbi.nlm.nih.gov/pubmed/37897020 http://dx.doi.org/10.3390/vaccines11101617 |
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