A 5-Lipoxygenase Inhibitor, Zileuton, Modulates Host Immune Responses and Improves Lung Function in a Model of Severe Acute Respiratory Syndrome (SARS) Induced by Betacoronavirus

Exacerbated inflammatory responses are a hallmark of severe coronavirus disease 2019 (COVID-19). Zileuton (Zi) is a selective inhibitor of 5-lipoxygenase, an enzyme involved in the production of several inflammatory/pro-resolving lipid mediators. Herein, we investigated the effect of Zi treatment in...

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Detalles Bibliográficos
Autores principales: Pereira, Rafaela das Dores, Rabelo, Rayane Aparecida Nonato, Oliveira, Natália Fernanda de Melo, Porto, Samuel Luiz Teixeira, Andrade, Ana Claudia dos Santos Pereira, Queiroz-Junior, Celso M., Barbosa, César Luís Nascimento, de Souza-Costa, Luiz Pedro, Santos, Felipe Rocha da Silva, Oliveira, Fernando Bento Rodrigues, da Silva, Bárbara Luísa Vieira, Umezu, Hanna L., Ferreira, Raquel, da Silva, Glauber S. F., Cruz, Jader Santos, Teixeira, Mauro Martins, Costa, Vivian Vasconcelos, Machado, Fabiana Simão
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611395/
https://www.ncbi.nlm.nih.gov/pubmed/37896826
http://dx.doi.org/10.3390/v15102049

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