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Geotricosis: fungemia en paciente con leucemia linfoblástica aguda
Fungemia caused by Geotrichum spp. is rare and highly lethal. The Instituto Nacional de Cancerología in Bogotá reported just two cases: one in the period 2001-2007 and the other in 2012-2018. This type of infection is more common in any kind of immunocompromised patients, so it can occur in those wi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Nacional de Salud
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611419/ https://www.ncbi.nlm.nih.gov/pubmed/37721920 http://dx.doi.org/10.7705/biomedica.6779 |
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author | Álvarez-Rodríguez, José Camilo Blanco-Bustos, María Paula Cuervo-Maldonado, Sonia Isabel Gómez-Rincón, Julio César Reyes, Ángela |
author_facet | Álvarez-Rodríguez, José Camilo Blanco-Bustos, María Paula Cuervo-Maldonado, Sonia Isabel Gómez-Rincón, Julio César Reyes, Ángela |
author_sort | Álvarez-Rodríguez, José Camilo |
collection | PubMed |
description | Fungemia caused by Geotrichum spp. is rare and highly lethal. The Instituto Nacional de Cancerología in Bogotá reported just two cases: one in the period 2001-2007 and the other in 2012-2018. This type of infection is more common in any kind of immunocompromised patients, so it can occur in those with hematological malignancies. Here we present the case of a 27-year-old man, diagnosed with acute lymphoblastic leukemia in relapse and admitted with polyarthralgia for five days, febrile neutropenia, non- abscessed cellulitis, and bacteremia due to methicillin-sensitive Staphylococcus aureus. The patient received therapy with oxacillin and cefepime, but the febrile neutropenia persisted. A new set of blood cultures was taken, and antifungal treatment was started because of the suspicion of invasive fungal infection. Arthroconidia were identified in blood cultures and Geotrichum spp. was confirmed using matrix-assisted laser desorption-ionization mass spectrometry. The antifungal treatment was adjusted with amphotericin B deoxycholate for 14 days and voriconazole for four weeks, and after a prolonged stay, the patient was discharged. Although the incidence of fungemia caused by Geotrichum spp. is low, it must be considered in patients with hematological malignancies and persistent febrile neutropenia despite the broadspectrum antimicrobial treatment. The confirmation of fungemia causing agents, with proteomic tools such as the mentioned mass spectrometry, allows treatment adjustment and decreases complications, hospital stay, and mortality. |
format | Online Article Text |
id | pubmed-10611419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Instituto Nacional de Salud |
record_format | MEDLINE/PubMed |
spelling | pubmed-106114192023-10-28 Geotricosis: fungemia en paciente con leucemia linfoblástica aguda Álvarez-Rodríguez, José Camilo Blanco-Bustos, María Paula Cuervo-Maldonado, Sonia Isabel Gómez-Rincón, Julio César Reyes, Ángela Biomedica Presentación De Caso Fungemia caused by Geotrichum spp. is rare and highly lethal. The Instituto Nacional de Cancerología in Bogotá reported just two cases: one in the period 2001-2007 and the other in 2012-2018. This type of infection is more common in any kind of immunocompromised patients, so it can occur in those with hematological malignancies. Here we present the case of a 27-year-old man, diagnosed with acute lymphoblastic leukemia in relapse and admitted with polyarthralgia for five days, febrile neutropenia, non- abscessed cellulitis, and bacteremia due to methicillin-sensitive Staphylococcus aureus. The patient received therapy with oxacillin and cefepime, but the febrile neutropenia persisted. A new set of blood cultures was taken, and antifungal treatment was started because of the suspicion of invasive fungal infection. Arthroconidia were identified in blood cultures and Geotrichum spp. was confirmed using matrix-assisted laser desorption-ionization mass spectrometry. The antifungal treatment was adjusted with amphotericin B deoxycholate for 14 days and voriconazole for four weeks, and after a prolonged stay, the patient was discharged. Although the incidence of fungemia caused by Geotrichum spp. is low, it must be considered in patients with hematological malignancies and persistent febrile neutropenia despite the broadspectrum antimicrobial treatment. The confirmation of fungemia causing agents, with proteomic tools such as the mentioned mass spectrometry, allows treatment adjustment and decreases complications, hospital stay, and mortality. Instituto Nacional de Salud 2023-08-31 /pmc/articles/PMC10611419/ /pubmed/37721920 http://dx.doi.org/10.7705/biomedica.6779 Text en https://creativecommons.org/licenses/by/4.0/Este es un artículo publicado en acceso abierto bajo una licencia Creative Commons |
spellingShingle | Presentación De Caso Álvarez-Rodríguez, José Camilo Blanco-Bustos, María Paula Cuervo-Maldonado, Sonia Isabel Gómez-Rincón, Julio César Reyes, Ángela Geotricosis: fungemia en paciente con leucemia linfoblástica aguda |
title | Geotricosis: fungemia en paciente con leucemia linfoblástica aguda |
title_full | Geotricosis: fungemia en paciente con leucemia linfoblástica aguda |
title_fullStr | Geotricosis: fungemia en paciente con leucemia linfoblástica aguda |
title_full_unstemmed | Geotricosis: fungemia en paciente con leucemia linfoblástica aguda |
title_short | Geotricosis: fungemia en paciente con leucemia linfoblástica aguda |
title_sort | geotricosis: fungemia en paciente con leucemia linfoblástica aguda |
topic | Presentación De Caso |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611419/ https://www.ncbi.nlm.nih.gov/pubmed/37721920 http://dx.doi.org/10.7705/biomedica.6779 |
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