Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme

The flavoenzyme nicotine oxidoreductase (NicA2) is a promising injectable treatment to aid in the cessation of smoking, a behavior responsible for one in ten deaths worldwide. NicA2 acts by degrading nicotine in the bloodstream before it reaches the brain. Clinical use of NicA2 is limited by its poo...

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Detalles Bibliográficos
Autores principales: Dulchavsky, Mark, Mitra, Rishav, Wu, Kevin, Li, Joshua, Boer, Karli, Liu, Xiaomeng, Zhang, Zhiyao, Vasquez, Cristian, Clark, Christopher T., Funckes, Kaitrin, Shankar, Kokila, Bonnet-Zahedi, Selene, Siddiq, Mohammad, Sepulveda, Yadira, Suhandynata, Raymond T., Momper, Jeremiah D., Calabrese, Antonio N., George, Olivier, Stull, Frederick, Bardwell, James C. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611581/
https://www.ncbi.nlm.nih.gov/pubmed/37770699
http://dx.doi.org/10.1038/s41589-023-01426-y

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