N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-terminal acetyltransferase and specific ubiquitin ligases. Biochem...

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Detalles Bibliográficos
Autores principales: Varland, Sylvia, Silva, Rui Duarte, Kjosås, Ine, Faustino, Alexandra, Bogaert, Annelies, Billmann, Maximilian, Boukhatmi, Hadi, Kellen, Barbara, Costanzo, Michael, Drazic, Adrian, Osberg, Camilla, Chan, Katherine, Zhang, Xiang, Tong, Amy Hin Yan, Andreazza, Simonetta, Lee, Juliette J., Nedyalkova, Lyudmila, Ušaj, Matej, Whitworth, Alexander J., Andrews, Brenda J., Moffat, Jason, Myers, Chad L., Gevaert, Kris, Boone, Charles, Martinho, Rui Gonçalo, Arnesen, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611716/
https://www.ncbi.nlm.nih.gov/pubmed/37891180
http://dx.doi.org/10.1038/s41467-023-42342-y

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