Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming

T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity. Terminally exhausted T cells are steadily replenished by a precursor population (Tpex), but the metabolic principles govern...

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Detalles Bibliográficos
Autores principales: Wu, Hao, Zhao, Xiufeng, Hochrein, Sophia M., Eckstein, Miriam, Gubert, Gabriela F., Knöpper, Konrad, Mansilla, Ana Maria, Öner, Arman, Doucet-Ladevèze, Remi, Schmitz, Werner, Ghesquière, Bart, Theurich, Sebastian, Dudek, Jan, Gasteiger, Georg, Zernecke, Alma, Kobold, Sebastian, Kastenmüller, Wolfgang, Vaeth, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611730/
https://www.ncbi.nlm.nih.gov/pubmed/37891230
http://dx.doi.org/10.1038/s41467-023-42634-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611730/
https://www.ncbi.nlm.nih.gov/pubmed/37891230
http://dx.doi.org/10.1038/s41467-023-42634-3

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