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Association of gait and cognition after surgery in patients with idiopathic normal pressure hydrocephalus

Idiopathic normal pressure hydrocephalus (iNPH) is a treatable disease in older adults. The association between gait and cognition has recently become a topic of interest. Sequential changes in this association were investigated in patients with iNPH using a newly developed statistical method. Data...

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Autores principales: Ishikawa, Masatsune, Mori, Etsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611736/
https://www.ncbi.nlm.nih.gov/pubmed/37891211
http://dx.doi.org/10.1038/s41598-023-45629-8
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author Ishikawa, Masatsune
Mori, Etsuro
author_facet Ishikawa, Masatsune
Mori, Etsuro
author_sort Ishikawa, Masatsune
collection PubMed
description Idiopathic normal pressure hydrocephalus (iNPH) is a treatable disease in older adults. The association between gait and cognition has recently become a topic of interest. Sequential changes in this association were investigated in patients with iNPH using a newly developed statistical method. Data were extracted from the SINPHONI-2 multicenter study on iNPH. Fifty patients who underwent shunt surgery were included in this study. Gait and cognition were assessed using the Timed Up and Go (TUG) and Mini-Mental State Examination (MMSE) tests. In addition to the MMSE total score, changes in the sub-item scores were examined. The ordinal sub-items of the MMSE are usually treated as continuous or categorical; however, both are unsuitable. An ordinal smoothing penalty with a generalized additive model enables precise statistical inference of ordinal and binary predictors. The TUG time improved significantly at 3, 6, and 12 months after surgery. The MMSE total scores increased without statistical significance. Preoperatively, there was no association between TUG time and MMSE sub-items. At 3 months, the “Registration,” ”3-step command,” “Read,” and “Copy” sub-items were statistically significant. The number of significant sub-items increased after 12 months. Thus, the association between gait and cognition gradually increased after surgery in patients with iNPH.
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spelling pubmed-106117362023-10-29 Association of gait and cognition after surgery in patients with idiopathic normal pressure hydrocephalus Ishikawa, Masatsune Mori, Etsuro Sci Rep Article Idiopathic normal pressure hydrocephalus (iNPH) is a treatable disease in older adults. The association between gait and cognition has recently become a topic of interest. Sequential changes in this association were investigated in patients with iNPH using a newly developed statistical method. Data were extracted from the SINPHONI-2 multicenter study on iNPH. Fifty patients who underwent shunt surgery were included in this study. Gait and cognition were assessed using the Timed Up and Go (TUG) and Mini-Mental State Examination (MMSE) tests. In addition to the MMSE total score, changes in the sub-item scores were examined. The ordinal sub-items of the MMSE are usually treated as continuous or categorical; however, both are unsuitable. An ordinal smoothing penalty with a generalized additive model enables precise statistical inference of ordinal and binary predictors. The TUG time improved significantly at 3, 6, and 12 months after surgery. The MMSE total scores increased without statistical significance. Preoperatively, there was no association between TUG time and MMSE sub-items. At 3 months, the “Registration,” ”3-step command,” “Read,” and “Copy” sub-items were statistically significant. The number of significant sub-items increased after 12 months. Thus, the association between gait and cognition gradually increased after surgery in patients with iNPH. Nature Publishing Group UK 2023-10-27 /pmc/articles/PMC10611736/ /pubmed/37891211 http://dx.doi.org/10.1038/s41598-023-45629-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ishikawa, Masatsune
Mori, Etsuro
Association of gait and cognition after surgery in patients with idiopathic normal pressure hydrocephalus
title Association of gait and cognition after surgery in patients with idiopathic normal pressure hydrocephalus
title_full Association of gait and cognition after surgery in patients with idiopathic normal pressure hydrocephalus
title_fullStr Association of gait and cognition after surgery in patients with idiopathic normal pressure hydrocephalus
title_full_unstemmed Association of gait and cognition after surgery in patients with idiopathic normal pressure hydrocephalus
title_short Association of gait and cognition after surgery in patients with idiopathic normal pressure hydrocephalus
title_sort association of gait and cognition after surgery in patients with idiopathic normal pressure hydrocephalus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611736/
https://www.ncbi.nlm.nih.gov/pubmed/37891211
http://dx.doi.org/10.1038/s41598-023-45629-8
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