Chromatinization modulates topoisomerase II processivity

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Type IIA topoisomerases are essential DNA processing enzymes that must robustly and reliably relax DNA torsional stress. While cellular processes constantly create varying torsional stress, how this variation impacts type IIA topoisomerase function remains obscure. Using multiple single-molecule app...

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Detalles Bibliográficos
Autores principales: Lee, Jaeyoon, Wu, Meiling, Inman, James T., Singh, Gundeep, Park, Seong ha, Lee, Joyce H., Fulbright, Robert M., Hong, Yifeng, Jeong, Joshua, Berger, James M., Wang, Michelle D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611788/
https://www.ncbi.nlm.nih.gov/pubmed/37891161
http://dx.doi.org/10.1038/s41467-023-42600-z
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