Quantification of P-glycoprotein function at the human blood-brain barrier using [(18)F]MC225 and PET

INTRODUCTION: P-glycoprotein (P-gp) is one of the most studied efflux transporters at the blood-brain barrier. It plays an important role in brain homeostasis by protecting the brain from a variety of endogenous and exogeneous substances. Changes in P-gp function are associated both with the onset o...

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Detalles Bibliográficos
Autores principales: Mossel, Pascalle, Arif, Wejdan M., De Souza, Giordana Salvi, Varela, Lara Garcia, van der Weijden, Chris W. J., Boersma, Hendrikus H., Willemsen, Antoon T. M., Boellaard, Ronald, Elsinga, Philip H., Borra, Ronald J. H., Dierckx, Rudi A. J. O., Lammertsma, Adriaan A., Bartels, Anna L., Luurtsema, Gert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611838/
https://www.ncbi.nlm.nih.gov/pubmed/37552369
http://dx.doi.org/10.1007/s00259-023-06363-5

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