Infliximab Ameliorates Methotrexate-Induced Nephrotoxicity in Experimental Rat Model: Impact on Oxidative Stress, Mitochondrial Biogenesis, Apoptotic and Autophagic Machineries

Accumulating data confirms that Methotrexate (MTX), a well-known immunosuppressive and anticancer drug, causes nephrotoxicity. Infliximab (INF), the inhibitor of tumor necrosis factor-alpha (TNF-α), was proven to have anti-inflammatory properties. Thus, it may have potential in preventing MTX-induce...

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Detalles Bibliográficos
Autores principales: Wasfey, Eman F., Shaaban, Marah, Essam, Manalia, Ayman, Youssef, Kamar, Salma, Mohasseb, Tasneem, Rozik, Rana, Khaled, Huda, Eladly, Mohamed, Elissawi, Mohammed, Bassem, Ahmed, Elshora, Shimaa Z., Radwan, Sara M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611839/
https://www.ncbi.nlm.nih.gov/pubmed/37656380
http://dx.doi.org/10.1007/s12013-023-01168-7

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