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Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism

It has been reported that volcanoes release several tonnes of mercury per year among other heavy metals through eruptions, fumaroles, or diffuse soil degassing. Since a high percentage of the world's population lives in the vicinity of an active volcano, the aim of this study is to evaluate the...

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Autores principales: Navarro-Sempere, A., Martínez-Peinado, P., Rodrigues, A. S., Garcia, P. V., Camarinho, R., Grindlay, G., Gras, L., García, M., Segovia, Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611846/
https://www.ncbi.nlm.nih.gov/pubmed/37580456
http://dx.doi.org/10.1007/s10653-023-01722-5
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author Navarro-Sempere, A.
Martínez-Peinado, P.
Rodrigues, A. S.
Garcia, P. V.
Camarinho, R.
Grindlay, G.
Gras, L.
García, M.
Segovia, Y.
author_facet Navarro-Sempere, A.
Martínez-Peinado, P.
Rodrigues, A. S.
Garcia, P. V.
Camarinho, R.
Grindlay, G.
Gras, L.
García, M.
Segovia, Y.
author_sort Navarro-Sempere, A.
collection PubMed
description It has been reported that volcanoes release several tonnes of mercury per year among other heavy metals through eruptions, fumaroles, or diffuse soil degassing. Since a high percentage of the world's population lives in the vicinity of an active volcano, the aim of this study is to evaluate the accumulation of these metals in the central nervous system and the presence of cellular mechanisms of heavy metal detoxification such as metallothioneins. To carry out this study, wild mice (Mus musculus) chronically exposed to an active volcanic environment were captured in Furnas village (Azores, Portugal) and compared with those trapped in a reference area (Rabo de Peixe, Azores, Portugal). On the one hand, the heavy metal load has been evaluated by analyzing brain and cerebellum using ICP-MS and a mercury analyzer and on the other hand, the presence of metallothionein 2A has been studied by immunofluorescence assays. Our results show a higher load of metals such as mercury, cadmium and lead in the central nervous system of exposed mice compared to non-exposed individuals and, in addition, a higher immunoreactivity for metallothionein 2A in different areas of the cerebrum and cerebellum indicating a possible neuroprotection process.
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spelling pubmed-106118462023-10-29 Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism Navarro-Sempere, A. Martínez-Peinado, P. Rodrigues, A. S. Garcia, P. V. Camarinho, R. Grindlay, G. Gras, L. García, M. Segovia, Y. Environ Geochem Health Original Paper It has been reported that volcanoes release several tonnes of mercury per year among other heavy metals through eruptions, fumaroles, or diffuse soil degassing. Since a high percentage of the world's population lives in the vicinity of an active volcano, the aim of this study is to evaluate the accumulation of these metals in the central nervous system and the presence of cellular mechanisms of heavy metal detoxification such as metallothioneins. To carry out this study, wild mice (Mus musculus) chronically exposed to an active volcanic environment were captured in Furnas village (Azores, Portugal) and compared with those trapped in a reference area (Rabo de Peixe, Azores, Portugal). On the one hand, the heavy metal load has been evaluated by analyzing brain and cerebellum using ICP-MS and a mercury analyzer and on the other hand, the presence of metallothionein 2A has been studied by immunofluorescence assays. Our results show a higher load of metals such as mercury, cadmium and lead in the central nervous system of exposed mice compared to non-exposed individuals and, in addition, a higher immunoreactivity for metallothionein 2A in different areas of the cerebrum and cerebellum indicating a possible neuroprotection process. Springer Netherlands 2023-08-14 2023 /pmc/articles/PMC10611846/ /pubmed/37580456 http://dx.doi.org/10.1007/s10653-023-01722-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Navarro-Sempere, A.
Martínez-Peinado, P.
Rodrigues, A. S.
Garcia, P. V.
Camarinho, R.
Grindlay, G.
Gras, L.
García, M.
Segovia, Y.
Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism
title Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism
title_full Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism
title_fullStr Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism
title_full_unstemmed Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism
title_short Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism
title_sort metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611846/
https://www.ncbi.nlm.nih.gov/pubmed/37580456
http://dx.doi.org/10.1007/s10653-023-01722-5
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