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Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis
Zero-dose children, or children who have not received any routine vaccination, are a priority population for global health policy makers as these children are at high risk of mortality from vaccine-preventable illnesses. We conducted a narrative review to identify potential interventions, both withi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612020/ https://www.ncbi.nlm.nih.gov/pubmed/37896868 http://dx.doi.org/10.3390/v15102092 |
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author | Ingle, Erin A. Shrestha, Priyanka Seth, Aparna Lalika, Mathias S. Azie, Jacinta I. Patel, Rena C. |
author_facet | Ingle, Erin A. Shrestha, Priyanka Seth, Aparna Lalika, Mathias S. Azie, Jacinta I. Patel, Rena C. |
author_sort | Ingle, Erin A. |
collection | PubMed |
description | Zero-dose children, or children who have not received any routine vaccination, are a priority population for global health policy makers as these children are at high risk of mortality from vaccine-preventable illnesses. We conducted a narrative review to identify potential interventions, both within and outside of the health sector, to reach zero-dose children. We reviewed the peer-reviewed and grey literature and identified 27 relevant resources. Additionally, we interviewed six key informants to enhance the synthesis of our findings. Data were organized into three priority settings: (1) urban slums, (2) remote or rural communities, and (3) conflict settings. We found that zero-dose children in the three priority settings face differing barriers to vaccination and, therefore, require context-specific interventions, such as leveraging slum health committees for urban slums or integrating with existing humanitarian response services for conflict settings. Three predominant themes emerged for grouping the various interventions: (1) community engagement, (2) health systems’ strengthening and integration, and (3) technological innovations. The barriers to reaching zero-dose children are multifaceted and nuanced to each setting, therefore, no one intervention is enough. Technological interventions especially must be coupled with community engagement and health systems’ strengthening efforts. Evaluations of the suggested interventions are needed to guide scale-up, as the evidence base around these interventions is relatively small. |
format | Online Article Text |
id | pubmed-10612020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106120202023-10-29 Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis Ingle, Erin A. Shrestha, Priyanka Seth, Aparna Lalika, Mathias S. Azie, Jacinta I. Patel, Rena C. Viruses Review Zero-dose children, or children who have not received any routine vaccination, are a priority population for global health policy makers as these children are at high risk of mortality from vaccine-preventable illnesses. We conducted a narrative review to identify potential interventions, both within and outside of the health sector, to reach zero-dose children. We reviewed the peer-reviewed and grey literature and identified 27 relevant resources. Additionally, we interviewed six key informants to enhance the synthesis of our findings. Data were organized into three priority settings: (1) urban slums, (2) remote or rural communities, and (3) conflict settings. We found that zero-dose children in the three priority settings face differing barriers to vaccination and, therefore, require context-specific interventions, such as leveraging slum health committees for urban slums or integrating with existing humanitarian response services for conflict settings. Three predominant themes emerged for grouping the various interventions: (1) community engagement, (2) health systems’ strengthening and integration, and (3) technological innovations. The barriers to reaching zero-dose children are multifaceted and nuanced to each setting, therefore, no one intervention is enough. Technological interventions especially must be coupled with community engagement and health systems’ strengthening efforts. Evaluations of the suggested interventions are needed to guide scale-up, as the evidence base around these interventions is relatively small. MDPI 2023-10-14 /pmc/articles/PMC10612020/ /pubmed/37896868 http://dx.doi.org/10.3390/v15102092 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ingle, Erin A. Shrestha, Priyanka Seth, Aparna Lalika, Mathias S. Azie, Jacinta I. Patel, Rena C. Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis |
title | Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis |
title_full | Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis |
title_fullStr | Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis |
title_full_unstemmed | Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis |
title_short | Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis |
title_sort | interventions to vaccinate zero-dose children: a narrative review and synthesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612020/ https://www.ncbi.nlm.nih.gov/pubmed/37896868 http://dx.doi.org/10.3390/v15102092 |
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