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Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis

Zero-dose children, or children who have not received any routine vaccination, are a priority population for global health policy makers as these children are at high risk of mortality from vaccine-preventable illnesses. We conducted a narrative review to identify potential interventions, both withi...

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Autores principales: Ingle, Erin A., Shrestha, Priyanka, Seth, Aparna, Lalika, Mathias S., Azie, Jacinta I., Patel, Rena C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612020/
https://www.ncbi.nlm.nih.gov/pubmed/37896868
http://dx.doi.org/10.3390/v15102092
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author Ingle, Erin A.
Shrestha, Priyanka
Seth, Aparna
Lalika, Mathias S.
Azie, Jacinta I.
Patel, Rena C.
author_facet Ingle, Erin A.
Shrestha, Priyanka
Seth, Aparna
Lalika, Mathias S.
Azie, Jacinta I.
Patel, Rena C.
author_sort Ingle, Erin A.
collection PubMed
description Zero-dose children, or children who have not received any routine vaccination, are a priority population for global health policy makers as these children are at high risk of mortality from vaccine-preventable illnesses. We conducted a narrative review to identify potential interventions, both within and outside of the health sector, to reach zero-dose children. We reviewed the peer-reviewed and grey literature and identified 27 relevant resources. Additionally, we interviewed six key informants to enhance the synthesis of our findings. Data were organized into three priority settings: (1) urban slums, (2) remote or rural communities, and (3) conflict settings. We found that zero-dose children in the three priority settings face differing barriers to vaccination and, therefore, require context-specific interventions, such as leveraging slum health committees for urban slums or integrating with existing humanitarian response services for conflict settings. Three predominant themes emerged for grouping the various interventions: (1) community engagement, (2) health systems’ strengthening and integration, and (3) technological innovations. The barriers to reaching zero-dose children are multifaceted and nuanced to each setting, therefore, no one intervention is enough. Technological interventions especially must be coupled with community engagement and health systems’ strengthening efforts. Evaluations of the suggested interventions are needed to guide scale-up, as the evidence base around these interventions is relatively small.
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spelling pubmed-106120202023-10-29 Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis Ingle, Erin A. Shrestha, Priyanka Seth, Aparna Lalika, Mathias S. Azie, Jacinta I. Patel, Rena C. Viruses Review Zero-dose children, or children who have not received any routine vaccination, are a priority population for global health policy makers as these children are at high risk of mortality from vaccine-preventable illnesses. We conducted a narrative review to identify potential interventions, both within and outside of the health sector, to reach zero-dose children. We reviewed the peer-reviewed and grey literature and identified 27 relevant resources. Additionally, we interviewed six key informants to enhance the synthesis of our findings. Data were organized into three priority settings: (1) urban slums, (2) remote or rural communities, and (3) conflict settings. We found that zero-dose children in the three priority settings face differing barriers to vaccination and, therefore, require context-specific interventions, such as leveraging slum health committees for urban slums or integrating with existing humanitarian response services for conflict settings. Three predominant themes emerged for grouping the various interventions: (1) community engagement, (2) health systems’ strengthening and integration, and (3) technological innovations. The barriers to reaching zero-dose children are multifaceted and nuanced to each setting, therefore, no one intervention is enough. Technological interventions especially must be coupled with community engagement and health systems’ strengthening efforts. Evaluations of the suggested interventions are needed to guide scale-up, as the evidence base around these interventions is relatively small. MDPI 2023-10-14 /pmc/articles/PMC10612020/ /pubmed/37896868 http://dx.doi.org/10.3390/v15102092 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ingle, Erin A.
Shrestha, Priyanka
Seth, Aparna
Lalika, Mathias S.
Azie, Jacinta I.
Patel, Rena C.
Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis
title Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis
title_full Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis
title_fullStr Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis
title_full_unstemmed Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis
title_short Interventions to Vaccinate Zero-Dose Children: A Narrative Review and Synthesis
title_sort interventions to vaccinate zero-dose children: a narrative review and synthesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612020/
https://www.ncbi.nlm.nih.gov/pubmed/37896868
http://dx.doi.org/10.3390/v15102092
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