Cargando…

Genetic Diversity of Domestic Cat Hepadnavirus in Southern Taiwan

Domestic cat hepadnavirus (DCH) is an infectious disease associated with chronic hepatitis in cats, which suggests a similarity with hepatitis B virus infections in humans. Since its first identification in Australia in 2018, DCH has been reported in several countries with varying prevalence rates,...

Descripción completa

Detalles Bibliográficos
Autores principales: Silva, Benji Brayan Ilagan, Chen, Jin-Yang, Villanueva, Brian Harvey Avanceña, Lu, Zi-Ying, Hsing, Hua-Zhen, Montecillo, Andrew D., Shofa, Maya, Minh, Hoang, Chuang, Jen-Pin, Huang, Huai-Ying, Saito, Akatsuki, Chuang, Kuo-Pin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612041/
https://www.ncbi.nlm.nih.gov/pubmed/37896905
http://dx.doi.org/10.3390/v15102128
_version_ 1785128613723504640
author Silva, Benji Brayan Ilagan
Chen, Jin-Yang
Villanueva, Brian Harvey Avanceña
Lu, Zi-Ying
Hsing, Hua-Zhen
Montecillo, Andrew D.
Shofa, Maya
Minh, Hoang
Chuang, Jen-Pin
Huang, Huai-Ying
Saito, Akatsuki
Chuang, Kuo-Pin
author_facet Silva, Benji Brayan Ilagan
Chen, Jin-Yang
Villanueva, Brian Harvey Avanceña
Lu, Zi-Ying
Hsing, Hua-Zhen
Montecillo, Andrew D.
Shofa, Maya
Minh, Hoang
Chuang, Jen-Pin
Huang, Huai-Ying
Saito, Akatsuki
Chuang, Kuo-Pin
author_sort Silva, Benji Brayan Ilagan
collection PubMed
description Domestic cat hepadnavirus (DCH) is an infectious disease associated with chronic hepatitis in cats, which suggests a similarity with hepatitis B virus infections in humans. Since its first identification in Australia in 2018, DCH has been reported in several countries with varying prevalence rates, but its presence in Taiwan has yet to be investigated. In this study, we aimed to identify the presence and genetic diversity of DCH infections in Taiwan. Among the 71 samples tested, eight (11.27%) were positive for DCH. Of these positive cases, three cats had elevated levels of alanine transaminase (ALT) and aspartate transaminase (AST), suggesting an association between DCH infection and chronic hepatitis. Four DCH-positive samples were also tested for feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) coinfection. One sample (25%) was positive for FIV, whereas there was no positive sample for FeLV (0%). In addition, we performed whole genome sequencing on six samples to determine the viral genome sequences. Phylogenetic analyses identified a distinct lineage compared with previously reported sequences. This study highlights the importance of continuous surveillance of DCH and further research to elucidate the pathophysiology and transmission route of DCH.
format Online
Article
Text
id pubmed-10612041
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106120412023-10-29 Genetic Diversity of Domestic Cat Hepadnavirus in Southern Taiwan Silva, Benji Brayan Ilagan Chen, Jin-Yang Villanueva, Brian Harvey Avanceña Lu, Zi-Ying Hsing, Hua-Zhen Montecillo, Andrew D. Shofa, Maya Minh, Hoang Chuang, Jen-Pin Huang, Huai-Ying Saito, Akatsuki Chuang, Kuo-Pin Viruses Article Domestic cat hepadnavirus (DCH) is an infectious disease associated with chronic hepatitis in cats, which suggests a similarity with hepatitis B virus infections in humans. Since its first identification in Australia in 2018, DCH has been reported in several countries with varying prevalence rates, but its presence in Taiwan has yet to be investigated. In this study, we aimed to identify the presence and genetic diversity of DCH infections in Taiwan. Among the 71 samples tested, eight (11.27%) were positive for DCH. Of these positive cases, three cats had elevated levels of alanine transaminase (ALT) and aspartate transaminase (AST), suggesting an association between DCH infection and chronic hepatitis. Four DCH-positive samples were also tested for feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) coinfection. One sample (25%) was positive for FIV, whereas there was no positive sample for FeLV (0%). In addition, we performed whole genome sequencing on six samples to determine the viral genome sequences. Phylogenetic analyses identified a distinct lineage compared with previously reported sequences. This study highlights the importance of continuous surveillance of DCH and further research to elucidate the pathophysiology and transmission route of DCH. MDPI 2023-10-20 /pmc/articles/PMC10612041/ /pubmed/37896905 http://dx.doi.org/10.3390/v15102128 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Silva, Benji Brayan Ilagan
Chen, Jin-Yang
Villanueva, Brian Harvey Avanceña
Lu, Zi-Ying
Hsing, Hua-Zhen
Montecillo, Andrew D.
Shofa, Maya
Minh, Hoang
Chuang, Jen-Pin
Huang, Huai-Ying
Saito, Akatsuki
Chuang, Kuo-Pin
Genetic Diversity of Domestic Cat Hepadnavirus in Southern Taiwan
title Genetic Diversity of Domestic Cat Hepadnavirus in Southern Taiwan
title_full Genetic Diversity of Domestic Cat Hepadnavirus in Southern Taiwan
title_fullStr Genetic Diversity of Domestic Cat Hepadnavirus in Southern Taiwan
title_full_unstemmed Genetic Diversity of Domestic Cat Hepadnavirus in Southern Taiwan
title_short Genetic Diversity of Domestic Cat Hepadnavirus in Southern Taiwan
title_sort genetic diversity of domestic cat hepadnavirus in southern taiwan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612041/
https://www.ncbi.nlm.nih.gov/pubmed/37896905
http://dx.doi.org/10.3390/v15102128
work_keys_str_mv AT silvabenjibrayanilagan geneticdiversityofdomesticcathepadnavirusinsoutherntaiwan
AT chenjinyang geneticdiversityofdomesticcathepadnavirusinsoutherntaiwan
AT villanuevabrianharveyavancena geneticdiversityofdomesticcathepadnavirusinsoutherntaiwan
AT luziying geneticdiversityofdomesticcathepadnavirusinsoutherntaiwan
AT hsinghuazhen geneticdiversityofdomesticcathepadnavirusinsoutherntaiwan
AT montecilloandrewd geneticdiversityofdomesticcathepadnavirusinsoutherntaiwan
AT shofamaya geneticdiversityofdomesticcathepadnavirusinsoutherntaiwan
AT minhhoang geneticdiversityofdomesticcathepadnavirusinsoutherntaiwan
AT chuangjenpin geneticdiversityofdomesticcathepadnavirusinsoutherntaiwan
AT huanghuaiying geneticdiversityofdomesticcathepadnavirusinsoutherntaiwan
AT saitoakatsuki geneticdiversityofdomesticcathepadnavirusinsoutherntaiwan
AT chuangkuopin geneticdiversityofdomesticcathepadnavirusinsoutherntaiwan