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Sequence-Based Antigenic Analyses of H1 Swine Influenza A Viruses from Colombia (2008–2021) Reveals Temporal and Geographical Antigenic Variations

Swine influenza is a respiratory disease that affects the pork industry and is a public health threat. It is caused by type A influenza virus (FLUAV), which continuously undergoes genetic and antigenic variations. A large amount of information regarding FLUAV in pigs is available worldwide, but it i...

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Autores principales: Ospina-Jimenez, Andres F., Gomez, Arlen P., Rincon-Monroy, Maria A., Ortiz, Lucia, Perez, Daniel R., Peña, Mario, Ramirez-Nieto, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612065/
https://www.ncbi.nlm.nih.gov/pubmed/37896808
http://dx.doi.org/10.3390/v15102030
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author Ospina-Jimenez, Andres F.
Gomez, Arlen P.
Rincon-Monroy, Maria A.
Ortiz, Lucia
Perez, Daniel R.
Peña, Mario
Ramirez-Nieto, Gloria
author_facet Ospina-Jimenez, Andres F.
Gomez, Arlen P.
Rincon-Monroy, Maria A.
Ortiz, Lucia
Perez, Daniel R.
Peña, Mario
Ramirez-Nieto, Gloria
author_sort Ospina-Jimenez, Andres F.
collection PubMed
description Swine influenza is a respiratory disease that affects the pork industry and is a public health threat. It is caused by type A influenza virus (FLUAV), which continuously undergoes genetic and antigenic variations. A large amount of information regarding FLUAV in pigs is available worldwide, but it is limited in Latin America. The HA sequences of H1 subtype FLUAV-positive samples obtained from pigs in Colombia between 2008–2021 were analyzed using sequence-based antigenic cartography and N-Glycosylation analyses. Of the 12 predicted global antigenic groups, Colombia contained five: four corresponding to pandemic strains and one to the classical swine H1N1 clade. Circulation of these clusters was observed in some regions during specific years. Ca2 was the immunodominant epitope among Colombian viruses. The counts of N-Glycosylation motifs were associated with the antigenic cluster ranging from three to five. The results show for the first time the existence of antigenic diversity of FLUAV in Colombia and highlight the impact of spatial and temporal factors on this diversity. This study provides information about FLUAV variability in pigs under natural conditions in the absence of vaccination and emphasizes the need for surveillance of its phylogenetic and antigenic characteristics.
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spelling pubmed-106120652023-10-29 Sequence-Based Antigenic Analyses of H1 Swine Influenza A Viruses from Colombia (2008–2021) Reveals Temporal and Geographical Antigenic Variations Ospina-Jimenez, Andres F. Gomez, Arlen P. Rincon-Monroy, Maria A. Ortiz, Lucia Perez, Daniel R. Peña, Mario Ramirez-Nieto, Gloria Viruses Article Swine influenza is a respiratory disease that affects the pork industry and is a public health threat. It is caused by type A influenza virus (FLUAV), which continuously undergoes genetic and antigenic variations. A large amount of information regarding FLUAV in pigs is available worldwide, but it is limited in Latin America. The HA sequences of H1 subtype FLUAV-positive samples obtained from pigs in Colombia between 2008–2021 were analyzed using sequence-based antigenic cartography and N-Glycosylation analyses. Of the 12 predicted global antigenic groups, Colombia contained five: four corresponding to pandemic strains and one to the classical swine H1N1 clade. Circulation of these clusters was observed in some regions during specific years. Ca2 was the immunodominant epitope among Colombian viruses. The counts of N-Glycosylation motifs were associated with the antigenic cluster ranging from three to five. The results show for the first time the existence of antigenic diversity of FLUAV in Colombia and highlight the impact of spatial and temporal factors on this diversity. This study provides information about FLUAV variability in pigs under natural conditions in the absence of vaccination and emphasizes the need for surveillance of its phylogenetic and antigenic characteristics. MDPI 2023-09-30 /pmc/articles/PMC10612065/ /pubmed/37896808 http://dx.doi.org/10.3390/v15102030 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ospina-Jimenez, Andres F.
Gomez, Arlen P.
Rincon-Monroy, Maria A.
Ortiz, Lucia
Perez, Daniel R.
Peña, Mario
Ramirez-Nieto, Gloria
Sequence-Based Antigenic Analyses of H1 Swine Influenza A Viruses from Colombia (2008–2021) Reveals Temporal and Geographical Antigenic Variations
title Sequence-Based Antigenic Analyses of H1 Swine Influenza A Viruses from Colombia (2008–2021) Reveals Temporal and Geographical Antigenic Variations
title_full Sequence-Based Antigenic Analyses of H1 Swine Influenza A Viruses from Colombia (2008–2021) Reveals Temporal and Geographical Antigenic Variations
title_fullStr Sequence-Based Antigenic Analyses of H1 Swine Influenza A Viruses from Colombia (2008–2021) Reveals Temporal and Geographical Antigenic Variations
title_full_unstemmed Sequence-Based Antigenic Analyses of H1 Swine Influenza A Viruses from Colombia (2008–2021) Reveals Temporal and Geographical Antigenic Variations
title_short Sequence-Based Antigenic Analyses of H1 Swine Influenza A Viruses from Colombia (2008–2021) Reveals Temporal and Geographical Antigenic Variations
title_sort sequence-based antigenic analyses of h1 swine influenza a viruses from colombia (2008–2021) reveals temporal and geographical antigenic variations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612065/
https://www.ncbi.nlm.nih.gov/pubmed/37896808
http://dx.doi.org/10.3390/v15102030
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