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Effect of a Second Pregnancy on the HPV Serology in Mothers Followed Up in the Finnish Family HPV Study

The impact of pregnancy on human papillomavirus (HPV) natural antibody levels is not fully understood. We tested the seroprevalence and levels of HPV 6, 11, 16, 18 and 45 antibodies at different time points among 89 women with a second pregnancy and 238 nonpregnant women during their 36-month follow...

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Autores principales: Suominen, Helmi, Suominen, Nelli, Syrjänen, Kari, Waterboer, Tim, Grénman, Seija, Syrjänen, Stina, Louvanto, Karolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612095/
https://www.ncbi.nlm.nih.gov/pubmed/37896886
http://dx.doi.org/10.3390/v15102109
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author Suominen, Helmi
Suominen, Nelli
Syrjänen, Kari
Waterboer, Tim
Grénman, Seija
Syrjänen, Stina
Louvanto, Karolina
author_facet Suominen, Helmi
Suominen, Nelli
Syrjänen, Kari
Waterboer, Tim
Grénman, Seija
Syrjänen, Stina
Louvanto, Karolina
author_sort Suominen, Helmi
collection PubMed
description The impact of pregnancy on human papillomavirus (HPV) natural antibody levels is not fully understood. We tested the seroprevalence and levels of HPV 6, 11, 16, 18 and 45 antibodies at different time points among 89 women with a second pregnancy and 238 nonpregnant women during their 36-month followup. All participants were unvaccinated for HPV and pregnant at the enrollment of the study. Serum samples were collected from the mothers at baseline and at the 12-month, 24-month, and 36-month followup visits. No statistically significant differences in mean antibody levels were observed in women who developed a second pregnancy compared to their nonpregnant counterparts. Between these two groups, statistically significant differences in serostatus were observed, particularly if the second pregnancy was ongoing at the 24-month timepoint. Accordingly, women with a second pregnancy were more likely to be seronegative for HPV 6, 11, 18, and 45 as compared to the nonpregnant women, the reverse being true for HPV16. In contrast, the women with an ongoing second pregnancy showed a higher prevalence of HPV16 seropositivity at the 36-month followup. These data suggest that a second pregnancy does not seem to have a major impact on the levels of HPV antibodies, but it might influence the serological outcomes.
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spelling pubmed-106120952023-10-29 Effect of a Second Pregnancy on the HPV Serology in Mothers Followed Up in the Finnish Family HPV Study Suominen, Helmi Suominen, Nelli Syrjänen, Kari Waterboer, Tim Grénman, Seija Syrjänen, Stina Louvanto, Karolina Viruses Article The impact of pregnancy on human papillomavirus (HPV) natural antibody levels is not fully understood. We tested the seroprevalence and levels of HPV 6, 11, 16, 18 and 45 antibodies at different time points among 89 women with a second pregnancy and 238 nonpregnant women during their 36-month followup. All participants were unvaccinated for HPV and pregnant at the enrollment of the study. Serum samples were collected from the mothers at baseline and at the 12-month, 24-month, and 36-month followup visits. No statistically significant differences in mean antibody levels were observed in women who developed a second pregnancy compared to their nonpregnant counterparts. Between these two groups, statistically significant differences in serostatus were observed, particularly if the second pregnancy was ongoing at the 24-month timepoint. Accordingly, women with a second pregnancy were more likely to be seronegative for HPV 6, 11, 18, and 45 as compared to the nonpregnant women, the reverse being true for HPV16. In contrast, the women with an ongoing second pregnancy showed a higher prevalence of HPV16 seropositivity at the 36-month followup. These data suggest that a second pregnancy does not seem to have a major impact on the levels of HPV antibodies, but it might influence the serological outcomes. MDPI 2023-10-18 /pmc/articles/PMC10612095/ /pubmed/37896886 http://dx.doi.org/10.3390/v15102109 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suominen, Helmi
Suominen, Nelli
Syrjänen, Kari
Waterboer, Tim
Grénman, Seija
Syrjänen, Stina
Louvanto, Karolina
Effect of a Second Pregnancy on the HPV Serology in Mothers Followed Up in the Finnish Family HPV Study
title Effect of a Second Pregnancy on the HPV Serology in Mothers Followed Up in the Finnish Family HPV Study
title_full Effect of a Second Pregnancy on the HPV Serology in Mothers Followed Up in the Finnish Family HPV Study
title_fullStr Effect of a Second Pregnancy on the HPV Serology in Mothers Followed Up in the Finnish Family HPV Study
title_full_unstemmed Effect of a Second Pregnancy on the HPV Serology in Mothers Followed Up in the Finnish Family HPV Study
title_short Effect of a Second Pregnancy on the HPV Serology in Mothers Followed Up in the Finnish Family HPV Study
title_sort effect of a second pregnancy on the hpv serology in mothers followed up in the finnish family hpv study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612095/
https://www.ncbi.nlm.nih.gov/pubmed/37896886
http://dx.doi.org/10.3390/v15102109
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