Cargando…

The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism

Coronavirus disease (COVID-19) and its outcomes remain one of the most challenging problems today. COVID-19 in children could be asymptomatic, but can result in a fatal outcome; therefore, predictions of the disease severity are important. The goal was to investigate the human genetic factors that c...

Descripción completa

Detalles Bibliográficos
Autores principales: Kozak, Kateryna, Pavlyshyn, Halyna, Kamyshnyi, Oleksandr, Shevchuk, Oksana, Korda, Mykhaylo, Vari, Sandor G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612096/
https://www.ncbi.nlm.nih.gov/pubmed/37896870
http://dx.doi.org/10.3390/v15102093
_version_ 1785128626625183744
author Kozak, Kateryna
Pavlyshyn, Halyna
Kamyshnyi, Oleksandr
Shevchuk, Oksana
Korda, Mykhaylo
Vari, Sandor G.
author_facet Kozak, Kateryna
Pavlyshyn, Halyna
Kamyshnyi, Oleksandr
Shevchuk, Oksana
Korda, Mykhaylo
Vari, Sandor G.
author_sort Kozak, Kateryna
collection PubMed
description Coronavirus disease (COVID-19) and its outcomes remain one of the most challenging problems today. COVID-19 in children could be asymptomatic, but can result in a fatal outcome; therefore, predictions of the disease severity are important. The goal was to investigate the human genetic factors that could be associated with COVID-19 severity in children. Single-nucleotide polymorphisms of the following genes were studied: ACE2 (rs2074192), IFNAR2 (rs2236757), TYK2 (rs2304256), OAS1 (rs10774671), OAS3 (rs10735079), CD40 (rs4813003), FCGR2A (rs1801274) and CASP3 (rs113420705). In the case–control study were 30 children with mild or moderate course of the disease; 30 with severe COVID-19 symptoms and multisystem inflammatory syndrome in children (MIS-C) and 15 who were healthy, and who did not have SARS-CoV-2 (PCR negative, Ig G negative). The study revealed that ACE2 rs2074192 (allele T), IFNAR2 rs2236757 (allele A), OAS1 rs10774671 (allele A), CD40 rs4813003 (allele C), CASP3 rs113420705 (allele C) and male sex contribute to severe COVID-19 course and MIS-C in 85.6% of cases. The World Health Organization reported that new SARS-CoV-2 variants may cause previously unseen symptoms in children. Although the study has limitations due to cohort size, the findings can help provide a better understanding of SARS-CoV-2 infection and proactive pediatric patient management.
format Online
Article
Text
id pubmed-10612096
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106120962023-10-29 The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism Kozak, Kateryna Pavlyshyn, Halyna Kamyshnyi, Oleksandr Shevchuk, Oksana Korda, Mykhaylo Vari, Sandor G. Viruses Article Coronavirus disease (COVID-19) and its outcomes remain one of the most challenging problems today. COVID-19 in children could be asymptomatic, but can result in a fatal outcome; therefore, predictions of the disease severity are important. The goal was to investigate the human genetic factors that could be associated with COVID-19 severity in children. Single-nucleotide polymorphisms of the following genes were studied: ACE2 (rs2074192), IFNAR2 (rs2236757), TYK2 (rs2304256), OAS1 (rs10774671), OAS3 (rs10735079), CD40 (rs4813003), FCGR2A (rs1801274) and CASP3 (rs113420705). In the case–control study were 30 children with mild or moderate course of the disease; 30 with severe COVID-19 symptoms and multisystem inflammatory syndrome in children (MIS-C) and 15 who were healthy, and who did not have SARS-CoV-2 (PCR negative, Ig G negative). The study revealed that ACE2 rs2074192 (allele T), IFNAR2 rs2236757 (allele A), OAS1 rs10774671 (allele A), CD40 rs4813003 (allele C), CASP3 rs113420705 (allele C) and male sex contribute to severe COVID-19 course and MIS-C in 85.6% of cases. The World Health Organization reported that new SARS-CoV-2 variants may cause previously unseen symptoms in children. Although the study has limitations due to cohort size, the findings can help provide a better understanding of SARS-CoV-2 infection and proactive pediatric patient management. MDPI 2023-10-14 /pmc/articles/PMC10612096/ /pubmed/37896870 http://dx.doi.org/10.3390/v15102093 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kozak, Kateryna
Pavlyshyn, Halyna
Kamyshnyi, Oleksandr
Shevchuk, Oksana
Korda, Mykhaylo
Vari, Sandor G.
The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism
title The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism
title_full The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism
title_fullStr The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism
title_full_unstemmed The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism
title_short The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism
title_sort relationship between covid-19 severity in children and immunoregulatory gene polymorphism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612096/
https://www.ncbi.nlm.nih.gov/pubmed/37896870
http://dx.doi.org/10.3390/v15102093
work_keys_str_mv AT kozakkateryna therelationshipbetweencovid19severityinchildrenandimmunoregulatorygenepolymorphism
AT pavlyshynhalyna therelationshipbetweencovid19severityinchildrenandimmunoregulatorygenepolymorphism
AT kamyshnyioleksandr therelationshipbetweencovid19severityinchildrenandimmunoregulatorygenepolymorphism
AT shevchukoksana therelationshipbetweencovid19severityinchildrenandimmunoregulatorygenepolymorphism
AT kordamykhaylo therelationshipbetweencovid19severityinchildrenandimmunoregulatorygenepolymorphism
AT varisandorg therelationshipbetweencovid19severityinchildrenandimmunoregulatorygenepolymorphism
AT kozakkateryna relationshipbetweencovid19severityinchildrenandimmunoregulatorygenepolymorphism
AT pavlyshynhalyna relationshipbetweencovid19severityinchildrenandimmunoregulatorygenepolymorphism
AT kamyshnyioleksandr relationshipbetweencovid19severityinchildrenandimmunoregulatorygenepolymorphism
AT shevchukoksana relationshipbetweencovid19severityinchildrenandimmunoregulatorygenepolymorphism
AT kordamykhaylo relationshipbetweencovid19severityinchildrenandimmunoregulatorygenepolymorphism
AT varisandorg relationshipbetweencovid19severityinchildrenandimmunoregulatorygenepolymorphism