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The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism
Coronavirus disease (COVID-19) and its outcomes remain one of the most challenging problems today. COVID-19 in children could be asymptomatic, but can result in a fatal outcome; therefore, predictions of the disease severity are important. The goal was to investigate the human genetic factors that c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612096/ https://www.ncbi.nlm.nih.gov/pubmed/37896870 http://dx.doi.org/10.3390/v15102093 |
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author | Kozak, Kateryna Pavlyshyn, Halyna Kamyshnyi, Oleksandr Shevchuk, Oksana Korda, Mykhaylo Vari, Sandor G. |
author_facet | Kozak, Kateryna Pavlyshyn, Halyna Kamyshnyi, Oleksandr Shevchuk, Oksana Korda, Mykhaylo Vari, Sandor G. |
author_sort | Kozak, Kateryna |
collection | PubMed |
description | Coronavirus disease (COVID-19) and its outcomes remain one of the most challenging problems today. COVID-19 in children could be asymptomatic, but can result in a fatal outcome; therefore, predictions of the disease severity are important. The goal was to investigate the human genetic factors that could be associated with COVID-19 severity in children. Single-nucleotide polymorphisms of the following genes were studied: ACE2 (rs2074192), IFNAR2 (rs2236757), TYK2 (rs2304256), OAS1 (rs10774671), OAS3 (rs10735079), CD40 (rs4813003), FCGR2A (rs1801274) and CASP3 (rs113420705). In the case–control study were 30 children with mild or moderate course of the disease; 30 with severe COVID-19 symptoms and multisystem inflammatory syndrome in children (MIS-C) and 15 who were healthy, and who did not have SARS-CoV-2 (PCR negative, Ig G negative). The study revealed that ACE2 rs2074192 (allele T), IFNAR2 rs2236757 (allele A), OAS1 rs10774671 (allele A), CD40 rs4813003 (allele C), CASP3 rs113420705 (allele C) and male sex contribute to severe COVID-19 course and MIS-C in 85.6% of cases. The World Health Organization reported that new SARS-CoV-2 variants may cause previously unseen symptoms in children. Although the study has limitations due to cohort size, the findings can help provide a better understanding of SARS-CoV-2 infection and proactive pediatric patient management. |
format | Online Article Text |
id | pubmed-10612096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106120962023-10-29 The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism Kozak, Kateryna Pavlyshyn, Halyna Kamyshnyi, Oleksandr Shevchuk, Oksana Korda, Mykhaylo Vari, Sandor G. Viruses Article Coronavirus disease (COVID-19) and its outcomes remain one of the most challenging problems today. COVID-19 in children could be asymptomatic, but can result in a fatal outcome; therefore, predictions of the disease severity are important. The goal was to investigate the human genetic factors that could be associated with COVID-19 severity in children. Single-nucleotide polymorphisms of the following genes were studied: ACE2 (rs2074192), IFNAR2 (rs2236757), TYK2 (rs2304256), OAS1 (rs10774671), OAS3 (rs10735079), CD40 (rs4813003), FCGR2A (rs1801274) and CASP3 (rs113420705). In the case–control study were 30 children with mild or moderate course of the disease; 30 with severe COVID-19 symptoms and multisystem inflammatory syndrome in children (MIS-C) and 15 who were healthy, and who did not have SARS-CoV-2 (PCR negative, Ig G negative). The study revealed that ACE2 rs2074192 (allele T), IFNAR2 rs2236757 (allele A), OAS1 rs10774671 (allele A), CD40 rs4813003 (allele C), CASP3 rs113420705 (allele C) and male sex contribute to severe COVID-19 course and MIS-C in 85.6% of cases. The World Health Organization reported that new SARS-CoV-2 variants may cause previously unseen symptoms in children. Although the study has limitations due to cohort size, the findings can help provide a better understanding of SARS-CoV-2 infection and proactive pediatric patient management. MDPI 2023-10-14 /pmc/articles/PMC10612096/ /pubmed/37896870 http://dx.doi.org/10.3390/v15102093 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kozak, Kateryna Pavlyshyn, Halyna Kamyshnyi, Oleksandr Shevchuk, Oksana Korda, Mykhaylo Vari, Sandor G. The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism |
title | The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism |
title_full | The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism |
title_fullStr | The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism |
title_full_unstemmed | The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism |
title_short | The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism |
title_sort | relationship between covid-19 severity in children and immunoregulatory gene polymorphism |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612096/ https://www.ncbi.nlm.nih.gov/pubmed/37896870 http://dx.doi.org/10.3390/v15102093 |
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