Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism

BACKGROUND: The PI3K/AKT pathway transduces the majority of the metabolic actions of insulin. In addition to cytosolic targets, insulin-stimulated phospho-AKT also translocates to mitochondria in the myocardium. Mouse models of diabetes exhibit impaired mitochondrial AKT signaling but the implicatio...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Han, Ta, Albert P., Chen, Yumay, Lee, Hsiao-Chen, Fan, Wenjun, Chen, Phang-Lang, Jordan, Maria C., Roos, Kenneth P., MacGregor, Grant R., Yang, Qin, Edwards, Robert A., Li, Junfeng, Wang, Ping H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612246/
https://www.ncbi.nlm.nih.gov/pubmed/37891673
http://dx.doi.org/10.1186/s12933-023-02020-1

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