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Discovery of novel 2,3,4,5-tetrahydrospiro[benzo[c]azepine-1,1’-cyclohexan]-5-ol derivatives as PARP-1 inhibitors

As an essential marker of cancer treatment, PARP-1 inhibitors could effectively kill tumor cells through a mechanism known as synthetic lethality and are used to treat a variety of cancers. In order to explore novel PARP-1 inhibitors, a series of 22 novel erythrina derivatives were reported and prel...

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Detalles Bibliográficos
Autores principales:	Yu, Ling, Li, Jian-hui, Zhu, Ju, Wang, You-de, Yan, Zhi-wei, Zhang, Li-ying, Li, Shuai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612255/ https://www.ncbi.nlm.nih.gov/pubmed/37891641 http://dx.doi.org/10.1186/s13065-023-01060-8

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