Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease

OBJECTIVE: Diabetic kidney disease (DKD) is characterized by the abnormal deposition of oxidized low-density lipoprotein (ox-LDL), which contributes to podocyte damage. Klotho, an aging suppressor that plays a critical role in protecting podocytes in DKD, is mainly expressed in kidney tubular epithe...

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Detalles Bibliográficos
Autores principales: Jiang, Wei, Gan, Chun, Zhou, Xindi, Yang, Qing, Chen, Dan, Xiao, Han, Dai, Lujun, Chen, Yaxi, Wang, Mo, Yang, Haiping, Li, Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612302/
https://www.ncbi.nlm.nih.gov/pubmed/37891556
http://dx.doi.org/10.1186/s12933-023-02025-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612302/
https://www.ncbi.nlm.nih.gov/pubmed/37891556
http://dx.doi.org/10.1186/s12933-023-02025-w

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