The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants

Mitogen-activated protein kinases 1 and 3 (MAPK1 and MAPK3), also called extracellular regulated kinases (ERK2 and ERK1), are serine/threonine kinase activated downstream by the Ras/Raf/MEK/ERK signal transduction cascade that regulates a variety of cellular processes. A dysregulation of MAPK cascad...

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Detalles Bibliográficos
Autores principales: Petrosino, Maria, Novak, Leonore, Pasquo, Alessandra, Turina, Paola, Capriotti, Emidio, Minicozzi, Velia, Consalvi, Valerio, Chiaraluce, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612357/
https://www.ncbi.nlm.nih.gov/pubmed/37891694
http://dx.doi.org/10.1186/s40246-023-00544-x

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