Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus

BACKGROUND: Insulin resistance (IR) is a major risk factor for Alzheimer’s disease (AD) dementia. The mechanisms by which IR predisposes to AD are not well-understood. Epigenetic studies may help identify molecular signatures of IR associated with AD, thus improving our understanding of the biologic...

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Detalles Bibliográficos
Autores principales: Sarnowski, Chloé, Huan, Tianxiao, Ma, Yiyi, Joehanes, Roby, Beiser, Alexa, DeCarli, Charles S., Heard-Costa, Nancy L., Levy, Daniel, Lin, Honghuang, Liu, Ching-Ti, Liu, Chunyu, Meigs, James B., Satizabal, Claudia L., Florez, Jose C., Hivert, Marie-France, Dupuis, Josée, De Jager, Philip L., Bennett, David A., Seshadri, Sudha, Morrison, Alanna C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612362/
https://www.ncbi.nlm.nih.gov/pubmed/37891690
http://dx.doi.org/10.1186/s13148-023-01589-4

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