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Lung adenocarcinoma in a patient with Lynch syndrome: a case report and literature review
This article presents a case of a 62-year-old Vietnamese woman with a history of Lynch syndrome (LS), who developed lung adenocarcinoma with EGFR L858R mutation. LS is an autosomal dominant cancer predisposition syndrome caused by a pathogenic germline variant in DNA mismatch repair genes, often lea...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613082/ https://www.ncbi.nlm.nih.gov/pubmed/37901336 http://dx.doi.org/10.3389/fonc.2023.1193503 |
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author | Hodges, Alan Sun, Kai Sheu, Tiffany G. Bernicker, Eric H. |
author_facet | Hodges, Alan Sun, Kai Sheu, Tiffany G. Bernicker, Eric H. |
author_sort | Hodges, Alan |
collection | PubMed |
description | This article presents a case of a 62-year-old Vietnamese woman with a history of Lynch syndrome (LS), who developed lung adenocarcinoma with EGFR L858R mutation. LS is an autosomal dominant cancer predisposition syndrome caused by a pathogenic germline variant in DNA mismatch repair genes, often leading to microsatellite instability. While LS is primarily associated with gastrointestinal, endometrial, ovarian, and urologic tract cancers, lung cancer accounts for less than 1% of LS-related cancers, with only six cases of LS-related lung cancer previously reported in the literature. The patient underwent multiple lines of treatment for her lung adenocarcinoma, including tyrosine kinase inhibitors, stereotactic body radiation therapy, pemetrexed and pembrolizumab, amivantamab, and fam-trastuzumab deruxtecan, but all resulted in only a partial response followed by a progressive disease. This case highlights the complex interplay of genetic cancer predisposition syndromes and the development of spontaneous driver mutations in the disease course and the subsequent management of tumors arising in these patients. |
format | Online Article Text |
id | pubmed-10613082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106130822023-10-29 Lung adenocarcinoma in a patient with Lynch syndrome: a case report and literature review Hodges, Alan Sun, Kai Sheu, Tiffany G. Bernicker, Eric H. Front Oncol Oncology This article presents a case of a 62-year-old Vietnamese woman with a history of Lynch syndrome (LS), who developed lung adenocarcinoma with EGFR L858R mutation. LS is an autosomal dominant cancer predisposition syndrome caused by a pathogenic germline variant in DNA mismatch repair genes, often leading to microsatellite instability. While LS is primarily associated with gastrointestinal, endometrial, ovarian, and urologic tract cancers, lung cancer accounts for less than 1% of LS-related cancers, with only six cases of LS-related lung cancer previously reported in the literature. The patient underwent multiple lines of treatment for her lung adenocarcinoma, including tyrosine kinase inhibitors, stereotactic body radiation therapy, pemetrexed and pembrolizumab, amivantamab, and fam-trastuzumab deruxtecan, but all resulted in only a partial response followed by a progressive disease. This case highlights the complex interplay of genetic cancer predisposition syndromes and the development of spontaneous driver mutations in the disease course and the subsequent management of tumors arising in these patients. Frontiers Media S.A. 2023-10-13 /pmc/articles/PMC10613082/ /pubmed/37901336 http://dx.doi.org/10.3389/fonc.2023.1193503 Text en Copyright © 2023 Hodges, Sun, Sheu and Bernicker https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Hodges, Alan Sun, Kai Sheu, Tiffany G. Bernicker, Eric H. Lung adenocarcinoma in a patient with Lynch syndrome: a case report and literature review |
title | Lung adenocarcinoma in a patient with Lynch syndrome: a case report and literature review |
title_full | Lung adenocarcinoma in a patient with Lynch syndrome: a case report and literature review |
title_fullStr | Lung adenocarcinoma in a patient with Lynch syndrome: a case report and literature review |
title_full_unstemmed | Lung adenocarcinoma in a patient with Lynch syndrome: a case report and literature review |
title_short | Lung adenocarcinoma in a patient with Lynch syndrome: a case report and literature review |
title_sort | lung adenocarcinoma in a patient with lynch syndrome: a case report and literature review |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613082/ https://www.ncbi.nlm.nih.gov/pubmed/37901336 http://dx.doi.org/10.3389/fonc.2023.1193503 |
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