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Heart Failure With Preserved Ejection Fraction: An Evolving Understanding
Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have signs and symptoms of HF due to high left ventricular (LV) filling pressure despite normal or near normal LV ejection fraction. It is more common than HF with reduced ejection fraction (HFrEF),...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613100/ https://www.ncbi.nlm.nih.gov/pubmed/37900404 http://dx.doi.org/10.7759/cureus.46152 |
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author | Tah, Sunanda Valderrama, Melissa Afzal, Maham Iqbal, Javed Farooq, Aisha Lak, Muhammad Ali Gostomczyk, Karol Jami, Elhama Kumar, Mahendra Sundaram, Akshay Sharifa, Mouhammad Arain, Mustafa |
author_facet | Tah, Sunanda Valderrama, Melissa Afzal, Maham Iqbal, Javed Farooq, Aisha Lak, Muhammad Ali Gostomczyk, Karol Jami, Elhama Kumar, Mahendra Sundaram, Akshay Sharifa, Mouhammad Arain, Mustafa |
author_sort | Tah, Sunanda |
collection | PubMed |
description | Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have signs and symptoms of HF due to high left ventricular (LV) filling pressure despite normal or near normal LV ejection fraction. It is more common than HF with reduced ejection fraction (HFrEF), and its diagnosis and treatment are more challenging than HFrEF. Although hypertension is the primary risk factor, coronary artery disease and other comorbidities, such as atrial fibrillation (AF), diabetes, chronic kidney disease (CKD), and obesity, also play an essential role in its formation. This review summarizes current knowledge about HFpEF, its pathophysiology, clinical presentation, diagnostic challenges, current treatments, and promising novel treatments. It is essential to continue to be updated on the latest treatments for HFpEF so that patients always receive the most therapeutic treatments. The use of GnRH agonists in the management of HFpEF, infusion of Apo a-I nanoparticle, low-level transcutaneous vagal stimulation (LLTS), and estrogen only in post-menopausal women are promising strategies to prevent diastolic dysfunction and HFpEF; however, there is still no proven curative treatment for HFpEF yet. |
format | Online Article Text |
id | pubmed-10613100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-106131002023-10-29 Heart Failure With Preserved Ejection Fraction: An Evolving Understanding Tah, Sunanda Valderrama, Melissa Afzal, Maham Iqbal, Javed Farooq, Aisha Lak, Muhammad Ali Gostomczyk, Karol Jami, Elhama Kumar, Mahendra Sundaram, Akshay Sharifa, Mouhammad Arain, Mustafa Cureus Cardiac/Thoracic/Vascular Surgery Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have signs and symptoms of HF due to high left ventricular (LV) filling pressure despite normal or near normal LV ejection fraction. It is more common than HF with reduced ejection fraction (HFrEF), and its diagnosis and treatment are more challenging than HFrEF. Although hypertension is the primary risk factor, coronary artery disease and other comorbidities, such as atrial fibrillation (AF), diabetes, chronic kidney disease (CKD), and obesity, also play an essential role in its formation. This review summarizes current knowledge about HFpEF, its pathophysiology, clinical presentation, diagnostic challenges, current treatments, and promising novel treatments. It is essential to continue to be updated on the latest treatments for HFpEF so that patients always receive the most therapeutic treatments. The use of GnRH agonists in the management of HFpEF, infusion of Apo a-I nanoparticle, low-level transcutaneous vagal stimulation (LLTS), and estrogen only in post-menopausal women are promising strategies to prevent diastolic dysfunction and HFpEF; however, there is still no proven curative treatment for HFpEF yet. Cureus 2023-09-28 /pmc/articles/PMC10613100/ /pubmed/37900404 http://dx.doi.org/10.7759/cureus.46152 Text en Copyright © 2023, Tah et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Cardiac/Thoracic/Vascular Surgery Tah, Sunanda Valderrama, Melissa Afzal, Maham Iqbal, Javed Farooq, Aisha Lak, Muhammad Ali Gostomczyk, Karol Jami, Elhama Kumar, Mahendra Sundaram, Akshay Sharifa, Mouhammad Arain, Mustafa Heart Failure With Preserved Ejection Fraction: An Evolving Understanding |
title | Heart Failure With Preserved Ejection Fraction: An Evolving Understanding |
title_full | Heart Failure With Preserved Ejection Fraction: An Evolving Understanding |
title_fullStr | Heart Failure With Preserved Ejection Fraction: An Evolving Understanding |
title_full_unstemmed | Heart Failure With Preserved Ejection Fraction: An Evolving Understanding |
title_short | Heart Failure With Preserved Ejection Fraction: An Evolving Understanding |
title_sort | heart failure with preserved ejection fraction: an evolving understanding |
topic | Cardiac/Thoracic/Vascular Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613100/ https://www.ncbi.nlm.nih.gov/pubmed/37900404 http://dx.doi.org/10.7759/cureus.46152 |
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