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Effect of flow rate ratio and positioning on a lighthouse tip ECMO return cannula
Extracorporeal membrane oxygenation is a life-saving support therapy in the case of cardiopulmonary refractory failure. Its use is associated to complications due to the presence of artificial surfaces and supraphysiological stress conditions. Thus, knowledge of the fluid structures associated to ea...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613146/ https://www.ncbi.nlm.nih.gov/pubmed/37454305 http://dx.doi.org/10.1007/s10237-023-01741-2 |
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author | Fiusco, Francesco Lemétayer, Julien Broman, Lars Mikael Prahl Wittberg, Lisa |
author_facet | Fiusco, Francesco Lemétayer, Julien Broman, Lars Mikael Prahl Wittberg, Lisa |
author_sort | Fiusco, Francesco |
collection | PubMed |
description | Extracorporeal membrane oxygenation is a life-saving support therapy in the case of cardiopulmonary refractory failure. Its use is associated to complications due to the presence of artificial surfaces and supraphysiological stress conditions. Thus, knowledge of the fluid structures associated to each component can give insight into sources of blood damage. In this study, an experimentally validated numerical study of a conventional lighthouse tip cannula in return configuration was carried out to characterize the flow structures using water or a Newtonian blood analog with different flow rate ratios and cannula positioning and their influence on hemolysis. The results showed that strong shear layers developed where the jets from the side holes met the co-flow. Stationary backflow regions at the vessel wall were also present downstream of the cannula. In the tilted case, the recirculation was much more pronounced on the wide side and almost absent on the narrow side. Small vortical backflow structures developed at the side holes which behaved like obstacles to the co-flow, creating pairs of counter-rotating vortices, which induced locally higher risk of hemolysis. However, global hemolysis index did not show significant deviations. Across the examined flow rate ratios, the holes on the narrow side consistently reinfused a larger fraction of fluid. A radial force developed in the tilted case in a direction so as to recenter the cannula in the vessel. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10237-023-01741-2. |
format | Online Article Text |
id | pubmed-10613146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-106131462023-10-30 Effect of flow rate ratio and positioning on a lighthouse tip ECMO return cannula Fiusco, Francesco Lemétayer, Julien Broman, Lars Mikael Prahl Wittberg, Lisa Biomech Model Mechanobiol Original Paper Extracorporeal membrane oxygenation is a life-saving support therapy in the case of cardiopulmonary refractory failure. Its use is associated to complications due to the presence of artificial surfaces and supraphysiological stress conditions. Thus, knowledge of the fluid structures associated to each component can give insight into sources of blood damage. In this study, an experimentally validated numerical study of a conventional lighthouse tip cannula in return configuration was carried out to characterize the flow structures using water or a Newtonian blood analog with different flow rate ratios and cannula positioning and their influence on hemolysis. The results showed that strong shear layers developed where the jets from the side holes met the co-flow. Stationary backflow regions at the vessel wall were also present downstream of the cannula. In the tilted case, the recirculation was much more pronounced on the wide side and almost absent on the narrow side. Small vortical backflow structures developed at the side holes which behaved like obstacles to the co-flow, creating pairs of counter-rotating vortices, which induced locally higher risk of hemolysis. However, global hemolysis index did not show significant deviations. Across the examined flow rate ratios, the holes on the narrow side consistently reinfused a larger fraction of fluid. A radial force developed in the tilted case in a direction so as to recenter the cannula in the vessel. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10237-023-01741-2. Springer Berlin Heidelberg 2023-07-16 2023 /pmc/articles/PMC10613146/ /pubmed/37454305 http://dx.doi.org/10.1007/s10237-023-01741-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Paper Fiusco, Francesco Lemétayer, Julien Broman, Lars Mikael Prahl Wittberg, Lisa Effect of flow rate ratio and positioning on a lighthouse tip ECMO return cannula |
title | Effect of flow rate ratio and positioning on a lighthouse tip ECMO return cannula |
title_full | Effect of flow rate ratio and positioning on a lighthouse tip ECMO return cannula |
title_fullStr | Effect of flow rate ratio and positioning on a lighthouse tip ECMO return cannula |
title_full_unstemmed | Effect of flow rate ratio and positioning on a lighthouse tip ECMO return cannula |
title_short | Effect of flow rate ratio and positioning on a lighthouse tip ECMO return cannula |
title_sort | effect of flow rate ratio and positioning on a lighthouse tip ecmo return cannula |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613146/ https://www.ncbi.nlm.nih.gov/pubmed/37454305 http://dx.doi.org/10.1007/s10237-023-01741-2 |
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