The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts

Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large part associated with R-loops, which hamper replication, especially at head-on transcription-replication conflicts (TRCs). Here we show that TRCs trigger a DNA Damage Response (DDR...

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Detalles Bibliográficos
Autores principales: Bayona-Feliu, Aleix, Herrera-Moyano, Emilia, Badra-Fajardo, Nibal, Galván-Femenía, Iván, Soler-Oliva, María Eugenia, Aguilera, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613258/
https://www.ncbi.nlm.nih.gov/pubmed/37898641
http://dx.doi.org/10.1038/s41467-023-42653-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613258/
https://www.ncbi.nlm.nih.gov/pubmed/37898641
http://dx.doi.org/10.1038/s41467-023-42653-0

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