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The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large part associated with R-loops, which hamper replication, especially at head-on transcription-replication conflicts (TRCs). Here we show that TRCs trigger a DNA Damage Response (DDR...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613258/ https://www.ncbi.nlm.nih.gov/pubmed/37898641 http://dx.doi.org/10.1038/s41467-023-42653-0 |