Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers–Danlos syndrome

Deficiency of an extracellular matrix glycoprotein tenascin-X (TNX) leads to a human heritable disorder Ehlers–Danlos syndrome, and TNX-deficient patients complain of chronic joint pain, myalgia, paresthesia, and axonal polyneuropathy. We previously reported that TNX-deficient (Tnxb(−/−)) mice exhib...

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Detalles Bibliográficos
Autores principales: Kamada, Hiroki, Emura, Kousuke, Yamamoto, Rikuto, Kawahara, Koichi, Uto, Sadahito, Minami, Toshiaki, Ito, Seiji, Matsumoto, Ken-ichi, Okuda-Ashitaka, Emiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613304/
https://www.ncbi.nlm.nih.gov/pubmed/37898719
http://dx.doi.org/10.1038/s41598-023-45638-7

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