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Exogenous IL-25 ameliorates airway neutrophilia via suppressing macrophage M1 polarization and the expression of IL-12 and IL-23 in asthma

BACKGROUND: Severe asthma is associated with substantial mortality and has unmet therapeutic need. A subset of severe asthma is characterized by neutrophilic airway inflammation. Classically activated (or M1) macrophages which express IL-12 and IL-23 are associated with airway neutrophilia in asthma...

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Detalles Bibliográficos
Autores principales:	Chang, Chenli, Chen, Gongqi, Wu, Wenliang, Chen, Dian, Chen, Shengchong, Gao, Jiali, Feng, Yuchen, Zhen, Guohua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613395/ https://www.ncbi.nlm.nih.gov/pubmed/37898756 http://dx.doi.org/10.1186/s12931-023-02557-5

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