Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1–srGAP1 pathway in a rat model of germinal matrix hemorrhage

BACKGROUND: Germinal matrix hemorrhage (GMH) is a devastating neonatal stroke, in which neuroinflammation is a critical pathological contributor. Slit2, a secreted extracellular matrix protein, plays a repulsive role in axon guidance and leukocyte chemotaxis via the roundabout1 (Robo1) receptor. Thi...

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Detalles Bibliográficos
Autores principales: Li, Qian, Huang, Lei, Ding, Yan, Sherchan, Prativa, Peng, Wenjie, Zhang, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613398/
https://www.ncbi.nlm.nih.gov/pubmed/37899442
http://dx.doi.org/10.1186/s12974-023-02935-2

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