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Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer’s Disease Mouse Model: Role of Microglial and Neuroinflammation

BACKGROUND: Microglia are closely linked to Alzheimer’s disease (AD) many years ago; however, the pathological mechanisms of AD remain unclear. The purpose of this study was to determine whether leptin affected microglia in the hippocampus of young and aged male APP/PS1 mice. OBJECTIVE: In a transge...

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Autores principales: Ma, Jing, Hou, Yi-Hui, Liao, Zhe-Yan, Ma, Zheng, Zhang, Xiao-Xuan, Wang, Jian-Li, Zhu, Yun-Bo, Shan, Hai-Lei, Wang, Ping-Yue, Li, Cheng-Bo, Lv, Ying-Lei, Wei, Yi-Lan, Dou, Jie-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613410/
https://www.ncbi.nlm.nih.gov/pubmed/37905186
http://dx.doi.org/10.2147/DNND.S427781
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author Ma, Jing
Hou, Yi-Hui
Liao, Zhe-Yan
Ma, Zheng
Zhang, Xiao-Xuan
Wang, Jian-Li
Zhu, Yun-Bo
Shan, Hai-Lei
Wang, Ping-Yue
Li, Cheng-Bo
Lv, Ying-Lei
Wei, Yi-Lan
Dou, Jie-Zhi
author_facet Ma, Jing
Hou, Yi-Hui
Liao, Zhe-Yan
Ma, Zheng
Zhang, Xiao-Xuan
Wang, Jian-Li
Zhu, Yun-Bo
Shan, Hai-Lei
Wang, Ping-Yue
Li, Cheng-Bo
Lv, Ying-Lei
Wei, Yi-Lan
Dou, Jie-Zhi
author_sort Ma, Jing
collection PubMed
description BACKGROUND: Microglia are closely linked to Alzheimer’s disease (AD) many years ago; however, the pathological mechanisms of AD remain unclear. The purpose of this study was to determine whether leptin affected microglia in the hippocampus of young and aged male APP/PS1 mice. OBJECTIVE: In a transgenic model of AD, we investigated the association between intraperitoneal injection of leptin and microglia. METHODS: We intraperitoneal injection of leptin (1mg/kg) every day for one week and analyzed inflammatory markers in microglia in the hippocampus of adult (6 months) and aged (12 months) APP/PS1 mice. RESULTS: In all leptin treatment group, the brain Aβ levels were decrease. We found increased levels of IL-1β, IL-6 and microglial activation in the hippocampus of adult mice. Using aged mice as an experimental model for chronic neuroinflammation and leptin resistance, the number of Iba-1+ microglia and the levels of IL-1β/IL-6 in the hippocampus were greatly increased as compared to the adult. But between the leptin treatment and un-treatment, there were no difference. CONCLUSION: Leptin signaling would regulate the activation of microglia and the release of inflammatory factors, but it is not the only underlying mechanism in the neuroprotective effects of AD pathogenesis.
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spelling pubmed-106134102023-10-30 Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer’s Disease Mouse Model: Role of Microglial and Neuroinflammation Ma, Jing Hou, Yi-Hui Liao, Zhe-Yan Ma, Zheng Zhang, Xiao-Xuan Wang, Jian-Li Zhu, Yun-Bo Shan, Hai-Lei Wang, Ping-Yue Li, Cheng-Bo Lv, Ying-Lei Wei, Yi-Lan Dou, Jie-Zhi Degener Neurol Neuromuscul Dis Original Research BACKGROUND: Microglia are closely linked to Alzheimer’s disease (AD) many years ago; however, the pathological mechanisms of AD remain unclear. The purpose of this study was to determine whether leptin affected microglia in the hippocampus of young and aged male APP/PS1 mice. OBJECTIVE: In a transgenic model of AD, we investigated the association between intraperitoneal injection of leptin and microglia. METHODS: We intraperitoneal injection of leptin (1mg/kg) every day for one week and analyzed inflammatory markers in microglia in the hippocampus of adult (6 months) and aged (12 months) APP/PS1 mice. RESULTS: In all leptin treatment group, the brain Aβ levels were decrease. We found increased levels of IL-1β, IL-6 and microglial activation in the hippocampus of adult mice. Using aged mice as an experimental model for chronic neuroinflammation and leptin resistance, the number of Iba-1+ microglia and the levels of IL-1β/IL-6 in the hippocampus were greatly increased as compared to the adult. But between the leptin treatment and un-treatment, there were no difference. CONCLUSION: Leptin signaling would regulate the activation of microglia and the release of inflammatory factors, but it is not the only underlying mechanism in the neuroprotective effects of AD pathogenesis. Dove 2023-10-25 /pmc/articles/PMC10613410/ /pubmed/37905186 http://dx.doi.org/10.2147/DNND.S427781 Text en © 2023 Ma et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Ma, Jing
Hou, Yi-Hui
Liao, Zhe-Yan
Ma, Zheng
Zhang, Xiao-Xuan
Wang, Jian-Li
Zhu, Yun-Bo
Shan, Hai-Lei
Wang, Ping-Yue
Li, Cheng-Bo
Lv, Ying-Lei
Wei, Yi-Lan
Dou, Jie-Zhi
Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer’s Disease Mouse Model: Role of Microglial and Neuroinflammation
title Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer’s Disease Mouse Model: Role of Microglial and Neuroinflammation
title_full Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer’s Disease Mouse Model: Role of Microglial and Neuroinflammation
title_fullStr Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer’s Disease Mouse Model: Role of Microglial and Neuroinflammation
title_full_unstemmed Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer’s Disease Mouse Model: Role of Microglial and Neuroinflammation
title_short Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer’s Disease Mouse Model: Role of Microglial and Neuroinflammation
title_sort neuroprotective effects of leptin on the app/ps1 alzheimer’s disease mouse model: role of microglial and neuroinflammation
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613410/
https://www.ncbi.nlm.nih.gov/pubmed/37905186
http://dx.doi.org/10.2147/DNND.S427781
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