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Left atrium 4D-flow segmentation with high-resolution contrast-enhanced magnetic resonance angiography

BACKGROUND: Atrial fibrillation (AF) leads to intracardiac thrombus and an associated risk of stroke. Phase-contrast cardiovascular magnetic resonance (CMR) with flow-encoding in all three spatial directions (4D-flow) provides a time-resolved 3D volume image with 3D blood velocity, which brings indi...

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Autores principales: Kim, Hansuk, Wilton, Stephen B., Garcia, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613494/
https://www.ncbi.nlm.nih.gov/pubmed/37904808
http://dx.doi.org/10.3389/fcvm.2023.1225922
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author Kim, Hansuk
Wilton, Stephen B.
Garcia, Julio
author_facet Kim, Hansuk
Wilton, Stephen B.
Garcia, Julio
author_sort Kim, Hansuk
collection PubMed
description BACKGROUND: Atrial fibrillation (AF) leads to intracardiac thrombus and an associated risk of stroke. Phase-contrast cardiovascular magnetic resonance (CMR) with flow-encoding in all three spatial directions (4D-flow) provides a time-resolved 3D volume image with 3D blood velocity, which brings individual hemodynamic information affecting thrombus formation. As the resolution and contrast of 4D-flow are limited, we proposed a semi-automated 4D-flow segmentation method for the left atrium (LA) using a standard-of-care contrast-enhanced magnetic resonance angiography (CE-MRA) and registration technique. METHODS: LA of 54 patients with AF were segmented from 4D-flow taken in sinus rhythm using two segmentation methods. (1) Phase-contrast magnetic resonance angiography (PC-MRA) was calculated from 4D-flow, and LA was segmented slice-by-slice manually. (2) LA and other structures were segmented from CE-MRA and transformed into 4D-flow coordinates by registration with the mutual information method. Overlap of volume was tested by the Dice similarity coefficient (DSC) and the average symmetric surface distance (ASSD). Mean velocity and stasis were calculated to compare the functional property of LA from two segmentation methods. RESULTS: LA volumes from segmentation on CE-MRA were strongly correlated with PC-MRA volume, although mean CE-MRA volumes were about 10% larger. The proposed registration scheme resulted in visually successful registration in 76% of cases after two rounds of registration. The mean of DSC of the registered cases was 0.770 ± 0.045, and the mean of ASSD was 2.704 mm ± 0.668 mm. Mean velocity had no significant difference between the two segmentation methods, and mean stasis had a 3.3% difference. CONCLUSION: The proposed CE-MRA segmentation and registration method can generate segmentation for 4D-flow images. This method will facilitate 4D-flow analysis for AF patients by making segmentation easier and overcoming the limit of resolution.
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spelling pubmed-106134942023-10-30 Left atrium 4D-flow segmentation with high-resolution contrast-enhanced magnetic resonance angiography Kim, Hansuk Wilton, Stephen B. Garcia, Julio Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Atrial fibrillation (AF) leads to intracardiac thrombus and an associated risk of stroke. Phase-contrast cardiovascular magnetic resonance (CMR) with flow-encoding in all three spatial directions (4D-flow) provides a time-resolved 3D volume image with 3D blood velocity, which brings individual hemodynamic information affecting thrombus formation. As the resolution and contrast of 4D-flow are limited, we proposed a semi-automated 4D-flow segmentation method for the left atrium (LA) using a standard-of-care contrast-enhanced magnetic resonance angiography (CE-MRA) and registration technique. METHODS: LA of 54 patients with AF were segmented from 4D-flow taken in sinus rhythm using two segmentation methods. (1) Phase-contrast magnetic resonance angiography (PC-MRA) was calculated from 4D-flow, and LA was segmented slice-by-slice manually. (2) LA and other structures were segmented from CE-MRA and transformed into 4D-flow coordinates by registration with the mutual information method. Overlap of volume was tested by the Dice similarity coefficient (DSC) and the average symmetric surface distance (ASSD). Mean velocity and stasis were calculated to compare the functional property of LA from two segmentation methods. RESULTS: LA volumes from segmentation on CE-MRA were strongly correlated with PC-MRA volume, although mean CE-MRA volumes were about 10% larger. The proposed registration scheme resulted in visually successful registration in 76% of cases after two rounds of registration. The mean of DSC of the registered cases was 0.770 ± 0.045, and the mean of ASSD was 2.704 mm ± 0.668 mm. Mean velocity had no significant difference between the two segmentation methods, and mean stasis had a 3.3% difference. CONCLUSION: The proposed CE-MRA segmentation and registration method can generate segmentation for 4D-flow images. This method will facilitate 4D-flow analysis for AF patients by making segmentation easier and overcoming the limit of resolution. Frontiers Media S.A. 2023-10-09 /pmc/articles/PMC10613494/ /pubmed/37904808 http://dx.doi.org/10.3389/fcvm.2023.1225922 Text en © 2023 Kim, Wilton and Garcia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Kim, Hansuk
Wilton, Stephen B.
Garcia, Julio
Left atrium 4D-flow segmentation with high-resolution contrast-enhanced magnetic resonance angiography
title Left atrium 4D-flow segmentation with high-resolution contrast-enhanced magnetic resonance angiography
title_full Left atrium 4D-flow segmentation with high-resolution contrast-enhanced magnetic resonance angiography
title_fullStr Left atrium 4D-flow segmentation with high-resolution contrast-enhanced magnetic resonance angiography
title_full_unstemmed Left atrium 4D-flow segmentation with high-resolution contrast-enhanced magnetic resonance angiography
title_short Left atrium 4D-flow segmentation with high-resolution contrast-enhanced magnetic resonance angiography
title_sort left atrium 4d-flow segmentation with high-resolution contrast-enhanced magnetic resonance angiography
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613494/
https://www.ncbi.nlm.nih.gov/pubmed/37904808
http://dx.doi.org/10.3389/fcvm.2023.1225922
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