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Higher abundance of Campylobacter in the oral microbiome of Japanese patients with moyamoya disease
Genetic factors alone cannot explain the pathophysiology of moyamoya disease (MMD), and environmental factors such as an immune response are thought to be involved. Oral and gut microbiomes have attracted attention as environmental factors in the pathophysiology of some vascular and autoimmune disea...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613609/ https://www.ncbi.nlm.nih.gov/pubmed/37899472 http://dx.doi.org/10.1038/s41598-023-45755-3 |
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author | Takayanagi, Kai Kanamori, Fumiaki Ishii, Kazuki Yokoyama, Kinya Araki, Yoshio Sumitomo, Masaki Maeda, Sachi Goto, Shunsaku Ota, Shinji Nagata, Yuichi Nishihori, Masahiro Maesawa, Satoshi Izumi, Takashi Takasu, Syuntaro Saito, Ryuta |
author_facet | Takayanagi, Kai Kanamori, Fumiaki Ishii, Kazuki Yokoyama, Kinya Araki, Yoshio Sumitomo, Masaki Maeda, Sachi Goto, Shunsaku Ota, Shinji Nagata, Yuichi Nishihori, Masahiro Maesawa, Satoshi Izumi, Takashi Takasu, Syuntaro Saito, Ryuta |
author_sort | Takayanagi, Kai |
collection | PubMed |
description | Genetic factors alone cannot explain the pathophysiology of moyamoya disease (MMD), and environmental factors such as an immune response are thought to be involved. Oral and gut microbiomes have attracted attention as environmental factors in the pathophysiology of some vascular and autoimmune diseases. However, the relationship between MMD and these microbiomes is yet to be thoroughly investigated. This prospective case–control study aimed to compare the microbiomes of Japanese patients with MMD with those of healthy individuals to identify the specific bacteria involved in MMD. Saliva and fecal samples were collected from 16 patients with MMD who had not undergone revascularization surgery. Fifteen healthy individuals were matched for age, sex, and body mass index. The microbiomes were determined using 16S rRNA sequencing and analyzed using QIIME2. Differentially abundant microbes were identified using LEfSE and ANCOM-BC. In the oral microbiome, the two analytical methods showed that Campylobacter was more abundant in patients with MMD than in healthy individuals. Differences in the gut microbiome were smaller than those in the oral microbiome. In conclusion, the oral microbiome profiles of patients with MMD significantly differ from those of healthy individuals. Campylobacter spp. could be a substantial environmental factor in the pathophysiology of MMD. |
format | Online Article Text |
id | pubmed-10613609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106136092023-10-31 Higher abundance of Campylobacter in the oral microbiome of Japanese patients with moyamoya disease Takayanagi, Kai Kanamori, Fumiaki Ishii, Kazuki Yokoyama, Kinya Araki, Yoshio Sumitomo, Masaki Maeda, Sachi Goto, Shunsaku Ota, Shinji Nagata, Yuichi Nishihori, Masahiro Maesawa, Satoshi Izumi, Takashi Takasu, Syuntaro Saito, Ryuta Sci Rep Article Genetic factors alone cannot explain the pathophysiology of moyamoya disease (MMD), and environmental factors such as an immune response are thought to be involved. Oral and gut microbiomes have attracted attention as environmental factors in the pathophysiology of some vascular and autoimmune diseases. However, the relationship between MMD and these microbiomes is yet to be thoroughly investigated. This prospective case–control study aimed to compare the microbiomes of Japanese patients with MMD with those of healthy individuals to identify the specific bacteria involved in MMD. Saliva and fecal samples were collected from 16 patients with MMD who had not undergone revascularization surgery. Fifteen healthy individuals were matched for age, sex, and body mass index. The microbiomes were determined using 16S rRNA sequencing and analyzed using QIIME2. Differentially abundant microbes were identified using LEfSE and ANCOM-BC. In the oral microbiome, the two analytical methods showed that Campylobacter was more abundant in patients with MMD than in healthy individuals. Differences in the gut microbiome were smaller than those in the oral microbiome. In conclusion, the oral microbiome profiles of patients with MMD significantly differ from those of healthy individuals. Campylobacter spp. could be a substantial environmental factor in the pathophysiology of MMD. Nature Publishing Group UK 2023-10-29 /pmc/articles/PMC10613609/ /pubmed/37899472 http://dx.doi.org/10.1038/s41598-023-45755-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Takayanagi, Kai Kanamori, Fumiaki Ishii, Kazuki Yokoyama, Kinya Araki, Yoshio Sumitomo, Masaki Maeda, Sachi Goto, Shunsaku Ota, Shinji Nagata, Yuichi Nishihori, Masahiro Maesawa, Satoshi Izumi, Takashi Takasu, Syuntaro Saito, Ryuta Higher abundance of Campylobacter in the oral microbiome of Japanese patients with moyamoya disease |
title | Higher abundance of Campylobacter in the oral microbiome of Japanese patients with moyamoya disease |
title_full | Higher abundance of Campylobacter in the oral microbiome of Japanese patients with moyamoya disease |
title_fullStr | Higher abundance of Campylobacter in the oral microbiome of Japanese patients with moyamoya disease |
title_full_unstemmed | Higher abundance of Campylobacter in the oral microbiome of Japanese patients with moyamoya disease |
title_short | Higher abundance of Campylobacter in the oral microbiome of Japanese patients with moyamoya disease |
title_sort | higher abundance of campylobacter in the oral microbiome of japanese patients with moyamoya disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613609/ https://www.ncbi.nlm.nih.gov/pubmed/37899472 http://dx.doi.org/10.1038/s41598-023-45755-3 |
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