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Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study
In Indonesia, the challenge of osteosarcoma progression is further worsened by patients' dependence on traditional massage therapy, low socio-economy, and educational status. This study aims to analyze the differences in the characteristics, laboratory findings, surgery techniques, degree of hi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613611/ https://www.ncbi.nlm.nih.gov/pubmed/37899365 http://dx.doi.org/10.1038/s41598-023-45808-7 |
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author | Karda, I Wayan Arya Mahendra Wan Ismail, Wan Faisham Kamal, Achmad Fauzi |
author_facet | Karda, I Wayan Arya Mahendra Wan Ismail, Wan Faisham Kamal, Achmad Fauzi |
author_sort | Karda, I Wayan Arya Mahendra |
collection | PubMed |
description | In Indonesia, the challenge of osteosarcoma progression is further worsened by patients' dependence on traditional massage therapy, low socio-economy, and educational status. This study aims to analyze the differences in the characteristics, laboratory findings, surgery techniques, degree of histopathological necrosis, and metastasis between osteosarcoma patients with and without prior massage manipulation therapy. This research is an analytical observational study with a prospective and retrospective cohort design. Patients were treated and followed for one year to evaluate the occurrence of metastasis. Prospective data was collected through interviews, and secondary data was collected from the patient's medical record. Of 84 subjects analyzed, 69% had a history of massage. There was an increase in LDH and ALP in patients with massage manipulation (p = 0.026). The median time to metastasis from baseline in the massage group (4 months) was statistically significant compared to the non-manipulation group (12 months) (p < 0.0001). This research found that massage therapy significantly increases LDH and ALP levels, making amputations more likely to be performed and a higher risk of metastasis that lowered the survival rate. The onset of metastasis was three times faster in patients with prior massage therapy. Therefore, we strongly recommend against massage manipulation therapy in osteosarcoma patients. |
format | Online Article Text |
id | pubmed-10613611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106136112023-10-31 Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study Karda, I Wayan Arya Mahendra Wan Ismail, Wan Faisham Kamal, Achmad Fauzi Sci Rep Article In Indonesia, the challenge of osteosarcoma progression is further worsened by patients' dependence on traditional massage therapy, low socio-economy, and educational status. This study aims to analyze the differences in the characteristics, laboratory findings, surgery techniques, degree of histopathological necrosis, and metastasis between osteosarcoma patients with and without prior massage manipulation therapy. This research is an analytical observational study with a prospective and retrospective cohort design. Patients were treated and followed for one year to evaluate the occurrence of metastasis. Prospective data was collected through interviews, and secondary data was collected from the patient's medical record. Of 84 subjects analyzed, 69% had a history of massage. There was an increase in LDH and ALP in patients with massage manipulation (p = 0.026). The median time to metastasis from baseline in the massage group (4 months) was statistically significant compared to the non-manipulation group (12 months) (p < 0.0001). This research found that massage therapy significantly increases LDH and ALP levels, making amputations more likely to be performed and a higher risk of metastasis that lowered the survival rate. The onset of metastasis was three times faster in patients with prior massage therapy. Therefore, we strongly recommend against massage manipulation therapy in osteosarcoma patients. Nature Publishing Group UK 2023-10-29 /pmc/articles/PMC10613611/ /pubmed/37899365 http://dx.doi.org/10.1038/s41598-023-45808-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Karda, I Wayan Arya Mahendra Wan Ismail, Wan Faisham Kamal, Achmad Fauzi Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study |
title | Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study |
title_full | Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study |
title_fullStr | Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study |
title_full_unstemmed | Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study |
title_short | Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study |
title_sort | massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613611/ https://www.ncbi.nlm.nih.gov/pubmed/37899365 http://dx.doi.org/10.1038/s41598-023-45808-7 |
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