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Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study

In Indonesia, the challenge of osteosarcoma progression is further worsened by patients' dependence on traditional massage therapy, low socio-economy, and educational status. This study aims to analyze the differences in the characteristics, laboratory findings, surgery techniques, degree of hi...

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Autores principales: Karda, I Wayan Arya Mahendra, Wan Ismail, Wan Faisham, Kamal, Achmad Fauzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613611/
https://www.ncbi.nlm.nih.gov/pubmed/37899365
http://dx.doi.org/10.1038/s41598-023-45808-7
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author Karda, I Wayan Arya Mahendra
Wan Ismail, Wan Faisham
Kamal, Achmad Fauzi
author_facet Karda, I Wayan Arya Mahendra
Wan Ismail, Wan Faisham
Kamal, Achmad Fauzi
author_sort Karda, I Wayan Arya Mahendra
collection PubMed
description In Indonesia, the challenge of osteosarcoma progression is further worsened by patients' dependence on traditional massage therapy, low socio-economy, and educational status. This study aims to analyze the differences in the characteristics, laboratory findings, surgery techniques, degree of histopathological necrosis, and metastasis between osteosarcoma patients with and without prior massage manipulation therapy. This research is an analytical observational study with a prospective and retrospective cohort design. Patients were treated and followed for one year to evaluate the occurrence of metastasis. Prospective data was collected through interviews, and secondary data was collected from the patient's medical record. Of 84 subjects analyzed, 69% had a history of massage. There was an increase in LDH and ALP in patients with massage manipulation (p = 0.026). The median time to metastasis from baseline in the massage group (4 months) was statistically significant compared to the non-manipulation group (12 months) (p < 0.0001). This research found that massage therapy significantly increases LDH and ALP levels, making amputations more likely to be performed and a higher risk of metastasis that lowered the survival rate. The onset of metastasis was three times faster in patients with prior massage therapy. Therefore, we strongly recommend against massage manipulation therapy in osteosarcoma patients.
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spelling pubmed-106136112023-10-31 Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study Karda, I Wayan Arya Mahendra Wan Ismail, Wan Faisham Kamal, Achmad Fauzi Sci Rep Article In Indonesia, the challenge of osteosarcoma progression is further worsened by patients' dependence on traditional massage therapy, low socio-economy, and educational status. This study aims to analyze the differences in the characteristics, laboratory findings, surgery techniques, degree of histopathological necrosis, and metastasis between osteosarcoma patients with and without prior massage manipulation therapy. This research is an analytical observational study with a prospective and retrospective cohort design. Patients were treated and followed for one year to evaluate the occurrence of metastasis. Prospective data was collected through interviews, and secondary data was collected from the patient's medical record. Of 84 subjects analyzed, 69% had a history of massage. There was an increase in LDH and ALP in patients with massage manipulation (p = 0.026). The median time to metastasis from baseline in the massage group (4 months) was statistically significant compared to the non-manipulation group (12 months) (p < 0.0001). This research found that massage therapy significantly increases LDH and ALP levels, making amputations more likely to be performed and a higher risk of metastasis that lowered the survival rate. The onset of metastasis was three times faster in patients with prior massage therapy. Therefore, we strongly recommend against massage manipulation therapy in osteosarcoma patients. Nature Publishing Group UK 2023-10-29 /pmc/articles/PMC10613611/ /pubmed/37899365 http://dx.doi.org/10.1038/s41598-023-45808-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Karda, I Wayan Arya Mahendra
Wan Ismail, Wan Faisham
Kamal, Achmad Fauzi
Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study
title Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study
title_full Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study
title_fullStr Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study
title_full_unstemmed Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study
title_short Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study
title_sort massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613611/
https://www.ncbi.nlm.nih.gov/pubmed/37899365
http://dx.doi.org/10.1038/s41598-023-45808-7
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