Cargando…

Evaluating immunological and inflammatory changes of treatment-experienced people living with HIV switching from first-line triple cART regimens to DTG/3TC vs. B/F/TAF: the DEBATE trial

BACKGROUND: The aim of this randomized clinical trial (RCT) was to compare immunological changes in virally suppressed people living with HIV (PLWH) switching from a three-drug regimen (3DR) to a two-drug regimen (2DR). METHODS: An open-label, prospective RCT enrolling PLWH receiving a 3DR who switc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cossarizza, Andrea, Cozzi-Lepri, Alessandro, Mattioli, Marco, Paolini, Annamaria, Neroni, Anita, De Biasi, Sara, Tartaro, Domenico Lo, Borella, Rebecca, Fidanza, Lucia, Gibellini, Lara, Beghetto, Barbara, Roncaglia, Enrica, Nardini, Giulia, Milic, Jovana, Menozzi, Marianna, Cuomo, Gianluca, Digaetano, Margherita, Orlando, Gabriella, Borghi, Vanni, Guaraldi, Giovanni, Mussini, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613634/ https://www.ncbi.nlm.nih.gov/pubmed/37908359 http://dx.doi.org/10.3389/fimmu.2023.1279390

Ejemplares similares

Plasma Cytokine Atlas Reveals the Importance of TH2 Polarization and Interferons in Predicting COVID-19 Severity and Survival
por: Gibellini, Lara, et al.
Publicado: (2022)

Prognostic immune markers identifying patients with severe COVID-19 who respond to tocilizumab
por: De Biasi, Sara, et al.
Publicado: (2023)

Patients Recovering from Severe COVID-19 Develop a Polyfunctional Antigen-Specific CD4+ T Cell Response
por: Paolini, Annamaria, et al.
Publicado: (2022)

A Comprehensive Analysis of Cytokine Network in Centenarians
por: Pinti, Marcello, et al.
Publicado: (2023)

Cell Death in Coronavirus Infections: Uncovering Its Role during COVID-19
por: Paolini, Annamaria, et al.
Publicado: (2021)

Detailed characterization of SARS-CoV-2-specific T and B cells after infection or heterologous vaccination
por: Lo Tartaro, Domenico, et al.
Publicado: (2023)

Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia
por: Gibellini, Lara, et al.
Publicado: (2020)

Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia
por: Lo Tartaro, Domenico, et al.
Publicado: (2022)

69. Incidence of metabolic complications among treatment-naïve adults living with HIV-1 randomized to B/F/TAF, DTG/ABC/3TC or DTG+F/TAF after 144 Weeks
por: Daar, Eric, et al.
Publicado: (2021)

Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
por: De Biasi, Sara, et al.
Publicado: (2020)

Acute myocarditis as the main clinical manifestation of SARS-CoV 2 infection
por: Cuomo, Gianluca, et al.
Publicado: (2020)

Epidemiology and Outcomes of Bloodstream Infections in HIV-Patients during a 13-Year Period
por: Franceschini, E., et al.
Publicado: (2020)

Author Correction: Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection
por: De Biasi, Sara, et al.
Publicado: (2021)

Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection
por: De Biasi, Sara, et al.
Publicado: (2021)

Redistribution of CD8+ T cell subsets in metastatic renal cell carcinoma patients treated with anti‐PD‐1 therapy
por: De Biasi, Sara, et al.
Publicado: (2022)

Impact of switching to TAF/FTC/RPV, TAF/FTC/EVG/cobi and ABC/3TC/DTG on cardiovascular risk and lipid profile in people living with HIV: a retrospective cohort study
por: Giacomelli, Andrea, et al.
Publicado: (2021)

Immunomodulation for the management of severe SARS-CoV2 infections. State of the art and review of the literature
por: Bacca, Erica, et al.
Publicado: (2021)

Better prognosis in females with severe COVID-19 pneumonia: possible role of inflammation as potential mediator
por: Mussini, Cristina, et al.
Publicado: (2021)

Re: ‘Methodological evaluation of bias in observational COVID-19 studies on drug effectiveness’ by Wolkewitz et al.
por: Cozzi-Lepri, Alessandro, et al.
Publicado: (2021)

Reliable and Accurate CD4+ T Cell Count and Percent by the Portable Flow Cytometer CyFlow MiniPOC and “CD4 Easy Count Kit-Dry”, as Revealed by the Comparison with the Gold Standard Dual Platform Technology
por: Nasi, Milena, et al.
Publicado: (2015)

T Cell Activation but Not Polyfunctionality after Primary HIV Infection Predicts Control of Viral Load and Length of the Time without Therapy
por: Cossarizza, Andrea, et al.
Publicado: (2012)

Molecular Imaging of Vascular Calcification with (18)F-Sodium-Fluoride in Patients Infected with Human Immunodeficiency Virus
por: Raggi, Paolo, et al.
Publicado: (2019)

Single-Cell Approaches to Profile the Response to Immune Checkpoint Inhibitors
por: Gibellini, Lara, et al.
Publicado: (2020)

Tocilizumab for severe COVID-19 pneumonia – Authors' reply
por: Guaraldi, Giovanni, et al.
Publicado: (2020)

Tocilizumab in COVID-19: finding the optimal route and dose – Authors' reply
por: Guaraldi, Giovanni, et al.
Publicado: (2020)

Evidence for mitochondrial Lonp1 expression in the nucleus
por: Gibellini, Lara, et al.
Publicado: (2022)

Dysfunctional subsets of CD39+ T cells, distinct from PD-1+, driven by leukemic extracellular vesicles in myeloid leukemias
por: Swatler, Julian, et al.
Publicado: (2022)

Synthesis and Anticancer Activity of CDDO and CDDO-Me, Two Derivatives of Natural Triterpenoids
por: Borella, Rebecca, et al.
Publicado: (2019)

Circulating and Tumor-Associated Neutrophils in the Era of Immune Checkpoint Inhibitors: Dynamics, Phenotypes, Metabolism, and Functions
por: Gibellini, Lara, et al.
Publicado: (2023)

First and second waves among hospitalised patients with COVID-19 with severe pneumonia: a comparison of 28-day mortality over the 1-year pandemic in a tertiary university hospital in Italy
por: Meschiari, Marianna, et al.
Publicado: (2022)

Impaired Mitochondrial Morphology and Functionality in Lonp1(wt/−) Mice
por: De Gaetano, Anna, et al.
Publicado: (2020)

Adherence to Lipid-Lowering Medication in People Living with HIV: An Outpatient Clinic Drug Direct Distribution Experience
por: Cuomo, Gianluca, et al.
Publicado: (2021)

1284. Suppressed Switch to DTG/3TC 2-Drug Regimen Vs. BIC- or DTG-Based 3-Drug Regimens
por: Pierone, Gerald, et al.
Publicado: (2022)

1561. Efficacy of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) Versus Dolutegravir (DTG)-Based 3-Drug Regimens in Adults With HIV Who Have Suboptimal Antiretroviral Adherence
por: Andreatta, Kristen, et al.
Publicado: (2023)

An observational comparison of first-line combination antiretroviral treatment (cART) with 2NRTI and ATV/r or DRV/r in HIV-infected patients in Italy
por: Cozzi-Lepri, Alessandro, et al.
Publicado: (2014)

Monocyte Distribution Width (MDW) as novel inflammatory marker with prognostic significance in COVID-19 patients
por: Riva, Giovanni, et al.
Publicado: (2021)

Aging with HIV vs. HIV Seroconversion at Older Age: A Diverse Population with Distinct Comorbidity Profiles
por: Guaraldi, Giovanni, et al.
Publicado: (2015)

Epidemiology and Risk Factors Associated With Mortality in Consecutive Patients With Bacterial Bloodstream Infection: Impact of MDR and XDR Bacteria
por: Santoro, Antonella, et al.
Publicado: (2020)

1024. Impact of Treatment Adherence on Efficacy of DTG/3TC and DTG + TDF/FTC: Pooled Analysis of the GEMINI 1 and 2 Clinical Trials
por: Ait-Khaled, Mounir, et al.
Publicado: (2020)

Another piece in the COVID-19 treatment puzzle
por: Mussini, Cristina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_58lc8ge80q65sqspp5bf6vvmg8