Cargando…

Unraveling the connection between gut microbiota and Alzheimer’s disease: a two-sample Mendelian randomization analysis

PURPOSE: Studies have shown a close relationship between gut microbiota (GM) and Alzheimer’s disease (AD). However, the causal relationship between them remains unclear. METHODS: We conducted a genome-wide association study (GWAS) using publicly available summary statistics data for GM and AD. We ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Huiqiong, Zhou, Kaixia, Zhuang, Yu, Li, Aidong, Luo, Baiwei, Zhang, Ye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613649/ https://www.ncbi.nlm.nih.gov/pubmed/37908561 http://dx.doi.org/10.3389/fnagi.2023.1273104

Ejemplares similares

No genetic causal association between Alzheimer’s disease and osteoporosis: A bidirectional two-sample Mendelian randomization study
por: Hu, Hongxin, et al.
Publicado: (2023)

Lipoprotein(a) and stroke: a two-sample Mendelian randomization study
por: Huang, Yi, et al.
Publicado: (2023)

Gut microbiota may be involved in Alzheimer’s disease pathology by dysregulating pyrimidine metabolism in APP/PS1 mice
por: Feng, Min, et al.
Publicado: (2022)

Mendelian randomization analyses of smoking and Alzheimer’s disease in Chinese and Japanese populations
por: Zhu, Yuan, et al.
Publicado: (2023)

Alterations of gut microbiota are associated with brain structural changes in the spectrum of Alzheimer's disease: the SILCODE study in Hainan cohort
por: He, Beiqi, et al.
Publicado: (2023)

Associations between polyunsaturated fatty acid concentrations and Parkinson’s disease: A two-sample Mendelian randomization study
por: Zhu, Xue, et al.
Publicado: (2023)

Effects of gut microbiota on neurodegenerative diseases
por: Khatoon, Saima, et al.
Publicado: (2023)

Genetically Predicted Levels of Circulating Inflammatory Cytokines and the Risk and Age at Onset of Parkinson’s Disease: A Two-Sample Mendelian Randomization Study
por: Zhao, Yating, et al.
Publicado: (2022)

Research trend of microbiota-gut-brain axis in Alzheimer’s disease based on CiteSpace (2012–2021): A bibliometrics analysis of 608 articles
por: Li, Zi-Long, et al.
Publicado: (2022)

Interactions between gut microbiota and Parkinson's disease: The role of microbiota-derived amino acid metabolism
por: Wang, Wang, et al.
Publicado: (2022)

Progressive structural and covariance connectivity abnormalities in patients with Alzheimer’s disease
por: Xiao, Yaqiong, et al.
Publicado: (2023)

Therapies for Parkinson’s disease and the gut microbiome: evidence for bidirectional connection
por: Hey, Grace, et al.
Publicado: (2023)

Sex differences in the structural rich-club connectivity in patients with Alzheimer’s disease
por: Kim, Soo-Jong, et al.
Publicado: (2023)

An eXplainability Artificial Intelligence approach to brain connectivity in Alzheimer's disease
por: Amoroso, Nicola, et al.
Publicado: (2023)

Contribution of preoperative gut microbiota in postoperative neurocognitive dysfunction in elderly patients undergoing orthopedic surgery
por: Bi, Jiangjiang, et al.
Publicado: (2023)

Classification of Alzheimer’s Disease Based on Abnormal Hippocampal Functional Connectivity and Machine Learning
por: Zhu, Qixiao, et al.
Publicado: (2022)

Differential Abnormality in Functional Connectivity Density in Preclinical and Early-Stage Alzheimer's Disease
por: Song, Yu, et al.
Publicado: (2022)

Sodium butyrate ameliorates gut dysfunction and motor deficits in a mouse model of Parkinson’s disease by regulating gut microbiota
por: Zhang, Yi, et al.
Publicado: (2023)

Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer's disease
por: Morrissey, Zachery D., et al.
Publicado: (2023)

Altered local and remote functional connectivity in mild Alzheimer’s disease patients with sleep disturbances
por: Wang, Lei, et al.
Publicado: (2023)

Increased functional connectivity patterns in mild Alzheimer’s disease: A rsfMRI study
por: Penalba-Sánchez, Lucía, et al.
Publicado: (2023)

An integrated neuroimaging-omics approach for the gut-brain communication pathways in Alzheimer’s disease
por: Sheng, Can, et al.
Publicado: (2023)

Novel insight into miRNA biology and its role in the pathogenesis of systemic lupus erythematosus
por: Luo, Baiwei, et al.
Publicado: (2022)

Inflammatory biomarkers and delirium: a Mendelian randomization study
por: Yu, Miao, et al.
Publicado: (2023)

Differences in gut microbiota correlate with symptoms and regional brain volumes in patients with late-life depression
por: Tsai, Chia-Fen, et al.
Publicado: (2022)

Altered gut microbiota in older adults with mild cognitive impairment: a case-control study
por: Fan, Kang-Chen, et al.
Publicado: (2023)

Gut microbiota and intestinal barrier function in subjects with cognitive impairments: a cross-sectional study
por: Pei, Ying, et al.
Publicado: (2023)

Aging brain shows joint declines in brain within-network connectivity and between-network connectivity: a large-sample study (N > 6,000)
por: Du, Yuhui, et al.
Publicado: (2023)

Bidirectional Mendelian randomization study of psychiatric disorders and Parkinson’s disease
por: Wu, Qi, et al.
Publicado: (2023)

Gut Microbiota Alteration Is Associated With Cognitive Deficits in Genetically Diabetic (Db/db) Mice During Aging
por: Zhang, Jiawei, et al.
Publicado: (2022)

Erratum: Investigating the association between polygenic risk scores for Alzheimer's disease with cognitive performance and intrinsic functional connectivity in healthy adults
Publicado: (2023)

Effects of the multidomain intervention with nutritional supplements on cognition and gut microbiome in early symptomatic Alzheimer’s disease: a randomized controlled trial
por: Lee, Eun Hye, et al.
Publicado: (2023)

Impact of alcohol-induced intestinal microbiota dysbiosis in a rodent model of Alzheimer’s disease
por: Frausto, Dulce M., et al.
Publicado: (2022)

Differences in resting state functional connectivity underlie visuomotor performance declines in older adults with a genetic risk (APOE ε4) for Alzheimer’s disease
por: Rogojin, Alica, et al.
Publicado: (2022)

Unraveling the transcriptomic signatures of Parkinson’s disease and major depression using single-cell and bulk data
por: Christodoulou, Christiana C., et al.
Publicado: (2023)

Unraveling the link: exploring the causal relationship between diabetes, multiple sclerosis, migraine, and Alzheimer’s disease through Mendelian randomization
por: Xue, Hua, et al.
Publicado: (2023)

Genetic Liability to Sedentary Behavior in Relation to Stroke, Its Subtypes and Neurodegenerative Diseases: A Mendelian Randomization Study
por: Yang, Fangkun, et al.
Publicado: (2021)

Transplantation of fecal microbiota from APP/PS1 mice and Alzheimer’s disease patients enhanced endoplasmic reticulum stress in the cerebral cortex of wild-type mice
por: Wang, Fang, et al.
Publicado: (2022)

Intrinsic Brain Activity of Inferior Temporal Region Increased in Prodromal Alzheimer's Disease With Hearing Loss
por: Hong, Luwei, et al.
Publicado: (2022)

Identification of Potential Driver Genes and Pathways Based on Transcriptomics Data in Alzheimer's Disease
por: Xia, Liang-Yong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hdk884mkq2dk2ujncm1e5j7fqf