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Central and peripheral analgesic active components of triterpenoid saponins from Stauntonia chinensis and their action mechanism

Triterpenoid saponins from Stauntonia chinensis have been proven to be a potential candidate for inflammatory pain relief. Our pharmacological studies confirmed that the analgesic role of triterpenoid saponins from S. chinensis occurred via a particular increase in the inhibitory synaptic response i...

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Autores principales: Gong, Ji-Hong, Zhang, Chang-Ming, Wu, Bo, Zhang, Zi-Xun, Zhou, Zhong-Yan, Zhu, Jia-Hui, Liu, Han, Rong, Yi, Yin, Qian, Chen, Ya-Ting, Zheng, Rong, Yang, Guang-Zhong, Yang, Xiao-Fei, Chen, Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613692/
https://www.ncbi.nlm.nih.gov/pubmed/37908974
http://dx.doi.org/10.3389/fphar.2023.1275041
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author Gong, Ji-Hong
Zhang, Chang-Ming
Wu, Bo
Zhang, Zi-Xun
Zhou, Zhong-Yan
Zhu, Jia-Hui
Liu, Han
Rong, Yi
Yin, Qian
Chen, Ya-Ting
Zheng, Rong
Yang, Guang-Zhong
Yang, Xiao-Fei
Chen, Su
author_facet Gong, Ji-Hong
Zhang, Chang-Ming
Wu, Bo
Zhang, Zi-Xun
Zhou, Zhong-Yan
Zhu, Jia-Hui
Liu, Han
Rong, Yi
Yin, Qian
Chen, Ya-Ting
Zheng, Rong
Yang, Guang-Zhong
Yang, Xiao-Fei
Chen, Su
author_sort Gong, Ji-Hong
collection PubMed
description Triterpenoid saponins from Stauntonia chinensis have been proven to be a potential candidate for inflammatory pain relief. Our pharmacological studies confirmed that the analgesic role of triterpenoid saponins from S. chinensis occurred via a particular increase in the inhibitory synaptic response in the cortex at resting state and the modulation of the capsaicin receptor. However, its analgesic active components and whether its analgesic mechanism are limited to this are not clear. In order to further determine its active components and analgesic mechanism, we used the patch clamp technique to screen the chemical components that can increase inhibitory synaptic response and antagonize transient receptor potential vanilloid 1, and then used in vivo animal experiments to evaluate the analgesic effect of the selected chemical components. Finally, we used the patch clamp technique and molecular biology technology to study the analgesic mechanism of the selected chemical components. The results showed that triterpenoid saponins from S. chinensis could enhance the inhibitory synaptic effect and antagonize the transient receptor potential vanilloid 1 through different chemical components, and produce central and peripheral analgesic effects. The above results fully reflect that “traditional Chinese medicine has multi-component, multi-target, and multi-channel synergistic regulation”.
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spelling pubmed-106136922023-10-31 Central and peripheral analgesic active components of triterpenoid saponins from Stauntonia chinensis and their action mechanism Gong, Ji-Hong Zhang, Chang-Ming Wu, Bo Zhang, Zi-Xun Zhou, Zhong-Yan Zhu, Jia-Hui Liu, Han Rong, Yi Yin, Qian Chen, Ya-Ting Zheng, Rong Yang, Guang-Zhong Yang, Xiao-Fei Chen, Su Front Pharmacol Pharmacology Triterpenoid saponins from Stauntonia chinensis have been proven to be a potential candidate for inflammatory pain relief. Our pharmacological studies confirmed that the analgesic role of triterpenoid saponins from S. chinensis occurred via a particular increase in the inhibitory synaptic response in the cortex at resting state and the modulation of the capsaicin receptor. However, its analgesic active components and whether its analgesic mechanism are limited to this are not clear. In order to further determine its active components and analgesic mechanism, we used the patch clamp technique to screen the chemical components that can increase inhibitory synaptic response and antagonize transient receptor potential vanilloid 1, and then used in vivo animal experiments to evaluate the analgesic effect of the selected chemical components. Finally, we used the patch clamp technique and molecular biology technology to study the analgesic mechanism of the selected chemical components. The results showed that triterpenoid saponins from S. chinensis could enhance the inhibitory synaptic effect and antagonize the transient receptor potential vanilloid 1 through different chemical components, and produce central and peripheral analgesic effects. The above results fully reflect that “traditional Chinese medicine has multi-component, multi-target, and multi-channel synergistic regulation”. Frontiers Media S.A. 2023-10-16 /pmc/articles/PMC10613692/ /pubmed/37908974 http://dx.doi.org/10.3389/fphar.2023.1275041 Text en Copyright © 2023 Gong, Zhang, Wu, Zhang, Zhou, Zhu, Liu, Rong, Yin, Chen, Zheng, Yang, Yang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Gong, Ji-Hong
Zhang, Chang-Ming
Wu, Bo
Zhang, Zi-Xun
Zhou, Zhong-Yan
Zhu, Jia-Hui
Liu, Han
Rong, Yi
Yin, Qian
Chen, Ya-Ting
Zheng, Rong
Yang, Guang-Zhong
Yang, Xiao-Fei
Chen, Su
Central and peripheral analgesic active components of triterpenoid saponins from Stauntonia chinensis and their action mechanism
title Central and peripheral analgesic active components of triterpenoid saponins from Stauntonia chinensis and their action mechanism
title_full Central and peripheral analgesic active components of triterpenoid saponins from Stauntonia chinensis and their action mechanism
title_fullStr Central and peripheral analgesic active components of triterpenoid saponins from Stauntonia chinensis and their action mechanism
title_full_unstemmed Central and peripheral analgesic active components of triterpenoid saponins from Stauntonia chinensis and their action mechanism
title_short Central and peripheral analgesic active components of triterpenoid saponins from Stauntonia chinensis and their action mechanism
title_sort central and peripheral analgesic active components of triterpenoid saponins from stauntonia chinensis and their action mechanism
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613692/
https://www.ncbi.nlm.nih.gov/pubmed/37908974
http://dx.doi.org/10.3389/fphar.2023.1275041
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