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Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort
PURPOSE: Thyroid hormones sensitivity is a newly proposed clinical entity closely related with metabolic health. Prior studies have reported the cross-sectional relationship between thyroid hormones sensitivity and diabetes; however, the longitudinal association is unclear to date. We aimed to explo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613705/ https://www.ncbi.nlm.nih.gov/pubmed/37908753 http://dx.doi.org/10.3389/fendo.2023.1267612 |
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author | Cui, Cancan Sui, He Wang, Zhijia Zhang, Te Zheng, Jia Yan, Han Li, Qianyu Mo, Zhanhao Liu, Lin |
author_facet | Cui, Cancan Sui, He Wang, Zhijia Zhang, Te Zheng, Jia Yan, Han Li, Qianyu Mo, Zhanhao Liu, Lin |
author_sort | Cui, Cancan |
collection | PubMed |
description | PURPOSE: Thyroid hormones sensitivity is a newly proposed clinical entity closely related with metabolic health. Prior studies have reported the cross-sectional relationship between thyroid hormones sensitivity and diabetes; however, the longitudinal association is unclear to date. We aimed to explore the relationship between impaired thyroid hormone sensitivity at baseline and diabetes onset using a cohort design. METHODS: This study enrolled 7283 euthyroid participants at the first visit between 2008 and 2009, and then annually followed until diabetes onset or 2019. Thyrotropin (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) were measured to calculate thyroid hormone sensitivity by thyroid feedback quantile-based index (TFQI), Chinese-referenced parametric thyroid feedback quantile-based index (PTFQI), thyrotropin index (TSHI), thyrotroph thyroxine resistance index (TT4RI) and FT3/FT4 ratio. Cox proportional hazard model and cross-lagged panel analysis were used. RESULTS: The mean baseline age was 44.2 ± 11.9 years, including 4170 (57.3%) male. During a median follow-up of 5.2 years, 359 cases developed diabetes. There was no significant association between thyroid hormones sensitivity indices and diabetes onset, and adjusted hazard ratios per unit (95% CIs) were 0.89 (0.65-1.23) for TFQI, 0.91 (0.57-1.45) for PTFQI, 0.95 (0.70-1.29) for TSHI, 0.98 (0.70-1.01) for TT4RI and 2.12 (0.17-5.78) for FT3/FT4 ratio. Cross-lagged analysis supported the temporal association from fasting glucose to impaired thyroid hormones sensitivity indices. CONCLUSIONS: Our findings could not demonstrate that thyroid hormones sensitivity status is a predictor of diabetes onset in the euthyroid population. Elevated fasting glucose (above 7.0 mmol/L) appeared to precede impaired sensitivity indices of thyroid hormones. |
format | Online Article Text |
id | pubmed-10613705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106137052023-10-31 Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort Cui, Cancan Sui, He Wang, Zhijia Zhang, Te Zheng, Jia Yan, Han Li, Qianyu Mo, Zhanhao Liu, Lin Front Endocrinol (Lausanne) Endocrinology PURPOSE: Thyroid hormones sensitivity is a newly proposed clinical entity closely related with metabolic health. Prior studies have reported the cross-sectional relationship between thyroid hormones sensitivity and diabetes; however, the longitudinal association is unclear to date. We aimed to explore the relationship between impaired thyroid hormone sensitivity at baseline and diabetes onset using a cohort design. METHODS: This study enrolled 7283 euthyroid participants at the first visit between 2008 and 2009, and then annually followed until diabetes onset or 2019. Thyrotropin (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) were measured to calculate thyroid hormone sensitivity by thyroid feedback quantile-based index (TFQI), Chinese-referenced parametric thyroid feedback quantile-based index (PTFQI), thyrotropin index (TSHI), thyrotroph thyroxine resistance index (TT4RI) and FT3/FT4 ratio. Cox proportional hazard model and cross-lagged panel analysis were used. RESULTS: The mean baseline age was 44.2 ± 11.9 years, including 4170 (57.3%) male. During a median follow-up of 5.2 years, 359 cases developed diabetes. There was no significant association between thyroid hormones sensitivity indices and diabetes onset, and adjusted hazard ratios per unit (95% CIs) were 0.89 (0.65-1.23) for TFQI, 0.91 (0.57-1.45) for PTFQI, 0.95 (0.70-1.29) for TSHI, 0.98 (0.70-1.01) for TT4RI and 2.12 (0.17-5.78) for FT3/FT4 ratio. Cross-lagged analysis supported the temporal association from fasting glucose to impaired thyroid hormones sensitivity indices. CONCLUSIONS: Our findings could not demonstrate that thyroid hormones sensitivity status is a predictor of diabetes onset in the euthyroid population. Elevated fasting glucose (above 7.0 mmol/L) appeared to precede impaired sensitivity indices of thyroid hormones. Frontiers Media S.A. 2023-10-16 /pmc/articles/PMC10613705/ /pubmed/37908753 http://dx.doi.org/10.3389/fendo.2023.1267612 Text en Copyright © 2023 Cui, Sui, Wang, Zhang, Zheng, Yan, Li, Mo and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Cui, Cancan Sui, He Wang, Zhijia Zhang, Te Zheng, Jia Yan, Han Li, Qianyu Mo, Zhanhao Liu, Lin Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort |
title | Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort |
title_full | Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort |
title_fullStr | Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort |
title_full_unstemmed | Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort |
title_short | Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort |
title_sort | thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613705/ https://www.ncbi.nlm.nih.gov/pubmed/37908753 http://dx.doi.org/10.3389/fendo.2023.1267612 |
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