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Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations

INTRODUCTION: Heterozygous mutations in GBA1, which encodes the lysosomal hydrolase glucocerebrosidase (GCase), are a common risk factor for the neurodegenerative movement disorder Parkinson's disease (PD). Consequently, therapeutic options targeting the GCase enzyme are in development. An impo...

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Detalles Bibliográficos
Autores principales:	Labrador-Garrido, Adahir, Zhong, Siying, Hughes, Laura, Keshiya, Shikara, Kim, Woojin S., Halliday, Glenda M., Dzamko, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613732/ https://www.ncbi.nlm.nih.gov/pubmed/37908374 http://dx.doi.org/10.3389/fncel.2023.1229213

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