The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye

BACKGROUND: Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with C...

Descripción completa

Detalles Bibliográficos
Autores principales: Gül, Fethi, Kasapoğlu, Umut Sabri, Sabaz, Mehmet Süleyman, Ay, Pınar, Doruk Oktay, Burçin, Çalışkan, Gülbahar, Demir, Nalan, Sayan, İsmet, Kabadayı, Feyyaz, Altuntaş, Gülsüm, Gümüş, Ayça, Kırca, Hülya, Şanlı, Deniz, Acil, Fatma, Dedeoğlu, Andaç, Ural, Sedef Gülçin, Akın Şen, İrem, Macit Aydın, Eda, Dayanır, Hakan, Yelken, Birgül, Ceylan, İlkay, Aydın, Osman Özcan, Eskidemir, Güneş, Aytekin, Ahmet, Cengiz, Melike, Arslan, Ülkü, Akdağ, Devrim, Alay, Gülçin Hilal, Tekin, Esra, Yarar, Volkan, Saracoğlu, Kemal Tolga, Gök, Funda, Alparslan, Volkan, Tuna, Verda, Yıldız, Murside, Şenoğlu, Nimet, Kıraklı, Cenk, Yıldırım, Süleyman, Saçar Kübüç, Kübra, Erer, Ayşen, Gültekin, Hamza, Özmen Süner, Kezban, Kuzgun, Özge, Öztürk, Çağatay Erman, Karahan, Aydın, Deveci, Okan, Ay, Mustafa, Tüfek Öztan, Dilara, Akıncı, Seda Banu, Solak, Melahat Yalçın, Bozbay, Süha, Özçiftçi, Serhat, Gönderen, Kamil, Küçük, Ahmet Oğuzhan, Uyan, Berna, Elay, Gülseren, Boyacı, Nazlıhan, Timurkaan, Mustafa, Karakoç, Ebru, Doğan, Lerzan, Yalçınkaya, Erdem, Kazancıoğlu, Leyla, Erdal Dönmez, Gül, Yılmaz, Barış, Ergül, Dursun Fırat, Boran, Maruf, Özkarakaş, Hüseyin, Karakaş, Buğra, Ergin Özcan, Perihan, Anaklı, İlkay, Bayar, Mustafa Kemal, Yüksel, Didem, Akdağ, Şükriye, Pişkin, Özcan, Temur, Sibel, Eyüpoğlu, Selin, Tekir Yılmaz, Elvan, Avcı, Gizem Zaim, Turan, Raziye, Alkan Bayburt, Fatma, Şahintürk, Helin, Güçyetmez, Bülent, Alparslan, Mustafa Muhlis, Yarıcı, Metin, Yıldırım, Fatma, Yektaş, Abdulkadir, Yaman, Güçlü, Demirkıran, Oktay, Cinel, İsmail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613737/
https://www.ncbi.nlm.nih.gov/pubmed/37867428
http://dx.doi.org/10.4274/balkanmedj.galenos.2023.2023-6-90
Descripción
Sumario:BACKGROUND: Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with COVID-19 remains unclear. AIMS: To determine the vaccination status and investigate the impact of the COVID-19 vaccine on the 28-day mortality in critically ill patients with COVID-19. STUDY DESIGN: Multicenter prospective observational clinical study. METHODS: This study was conducted in 60 hospitals with ICUs managing critically ill patients with COVID-19. Patients aged ≥ 18 years with confirmed COVID-19 who were admitted to the ICU were included. The present study had two phases. The first phase was designed as a one-day point prevalence study, and demographic and clinical findings were evaluated. In the second phase, the 28-day mortality was evaluated. RESULTS: As of August 11, 2021, 921 patients were enrolled in the study. The mean age of the patients was 65.42 ± 16.74 years, and 48.6% (n = 448) were female. Among the critically ill patients with COVID-19, 52.6% (n = 484) were unvaccinated, 7.7% (n = 71) were incompletely vaccinated, and 39.8% (n = 366) were fully vaccinated. A subgroup analysis of 817 patients who were unvaccinated (n = 484) or who had received two doses of the CoronaVac vaccine (n = 333) was performed. The 28-day mortality rate was 56.8% (n = 275) and 57.4% (n = 191) in the unvaccinated and two-dose CoronaVac groups, respectively. The 28-day mortality was associated with age, hypertension, the number of comorbidities, type of respiratory support, and APACHE II and sequential organ failure assessment scores (p < 0.05). The odds ratio for the 28-day mortality among those who had received two doses of CoronaVac was 0.591 (95% confidence interval: 0.413-0.848) (p = 0.004). CONCLUSION: Vaccination with at least two doses of CoronaVac within six months significantly decreased mortality in vaccinated patients than in unvaccinated patients.

Ejemplares similares