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The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye
BACKGROUND: Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with C...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Galenos Publishing
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613737/ https://www.ncbi.nlm.nih.gov/pubmed/37867428 http://dx.doi.org/10.4274/balkanmedj.galenos.2023.2023-6-90 |
| _version_ | 1785128894287839232 |
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| author | Gül, Fethi Kasapoğlu, Umut Sabri Sabaz, Mehmet Süleyman Ay, Pınar Doruk Oktay, Burçin Çalışkan, Gülbahar Demir, Nalan Sayan, İsmet Kabadayı, Feyyaz Altuntaş, Gülsüm Gümüş, Ayça Kırca, Hülya Şanlı, Deniz Acil, Fatma Dedeoğlu, Andaç Ural, Sedef Gülçin Akın Şen, İrem Macit Aydın, Eda Dayanır, Hakan Yelken, Birgül Ceylan, İlkay Aydın, Osman Özcan Eskidemir, Güneş Aytekin, Ahmet Cengiz, Melike Arslan, Ülkü Akdağ, Devrim Alay, Gülçin Hilal Tekin, Esra Yarar, Volkan Saracoğlu, Kemal Tolga Gök, Funda Alparslan, Volkan Tuna, Verda Yıldız, Murside Şenoğlu, Nimet Kıraklı, Cenk Yıldırım, Süleyman Saçar Kübüç, Kübra Erer, Ayşen Gültekin, Hamza Özmen Süner, Kezban Kuzgun, Özge Öztürk, Çağatay Erman Karahan, Aydın Deveci, Okan Ay, Mustafa Tüfek Öztan, Dilara Akıncı, Seda Banu Solak, Melahat Yalçın Bozbay, Süha Özçiftçi, Serhat Gönderen, Kamil Küçük, Ahmet Oğuzhan Uyan, Berna Elay, Gülseren Boyacı, Nazlıhan Timurkaan, Mustafa Karakoç, Ebru Doğan, Lerzan Yalçınkaya, Erdem Kazancıoğlu, Leyla Erdal Dönmez, Gül Yılmaz, Barış Ergül, Dursun Fırat Boran, Maruf Özkarakaş, Hüseyin Karakaş, Buğra Ergin Özcan, Perihan Anaklı, İlkay Bayar, Mustafa Kemal Yüksel, Didem Akdağ, Şükriye Pişkin, Özcan Temur, Sibel Eyüpoğlu, Selin Tekir Yılmaz, Elvan Avcı, Gizem Zaim Turan, Raziye Alkan Bayburt, Fatma Şahintürk, Helin Güçyetmez, Bülent Alparslan, Mustafa Muhlis Yarıcı, Metin Yıldırım, Fatma Yektaş, Abdulkadir Yaman, Güçlü Demirkıran, Oktay Cinel, İsmail |
| author_facet | Gül, Fethi Kasapoğlu, Umut Sabri Sabaz, Mehmet Süleyman Ay, Pınar Doruk Oktay, Burçin Çalışkan, Gülbahar Demir, Nalan Sayan, İsmet Kabadayı, Feyyaz Altuntaş, Gülsüm Gümüş, Ayça Kırca, Hülya Şanlı, Deniz Acil, Fatma Dedeoğlu, Andaç Ural, Sedef Gülçin Akın Şen, İrem Macit Aydın, Eda Dayanır, Hakan Yelken, Birgül Ceylan, İlkay Aydın, Osman Özcan Eskidemir, Güneş Aytekin, Ahmet Cengiz, Melike Arslan, Ülkü Akdağ, Devrim Alay, Gülçin Hilal Tekin, Esra Yarar, Volkan Saracoğlu, Kemal Tolga Gök, Funda Alparslan, Volkan Tuna, Verda Yıldız, Murside Şenoğlu, Nimet Kıraklı, Cenk Yıldırım, Süleyman Saçar Kübüç, Kübra Erer, Ayşen Gültekin, Hamza Özmen Süner, Kezban Kuzgun, Özge Öztürk, Çağatay Erman Karahan, Aydın Deveci, Okan Ay, Mustafa Tüfek Öztan, Dilara Akıncı, Seda Banu Solak, Melahat Yalçın Bozbay, Süha Özçiftçi, Serhat Gönderen, Kamil Küçük, Ahmet Oğuzhan Uyan, Berna Elay, Gülseren Boyacı, Nazlıhan Timurkaan, Mustafa Karakoç, Ebru Doğan, Lerzan Yalçınkaya, Erdem Kazancıoğlu, Leyla Erdal Dönmez, Gül Yılmaz, Barış Ergül, Dursun Fırat Boran, Maruf Özkarakaş, Hüseyin Karakaş, Buğra Ergin Özcan, Perihan Anaklı, İlkay Bayar, Mustafa Kemal Yüksel, Didem Akdağ, Şükriye Pişkin, Özcan Temur, Sibel Eyüpoğlu, Selin Tekir Yılmaz, Elvan Avcı, Gizem Zaim Turan, Raziye Alkan Bayburt, Fatma Şahintürk, Helin Güçyetmez, Bülent Alparslan, Mustafa Muhlis Yarıcı, Metin Yıldırım, Fatma Yektaş, Abdulkadir Yaman, Güçlü Demirkıran, Oktay Cinel, İsmail |
| author_sort | Gül, Fethi |
| collection | PubMed |
| description | BACKGROUND: Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with COVID-19 remains unclear. AIMS: To determine the vaccination status and investigate the impact of the COVID-19 vaccine on the 28-day mortality in critically ill patients with COVID-19. STUDY DESIGN: Multicenter prospective observational clinical study. METHODS: This study was conducted in 60 hospitals with ICUs managing critically ill patients with COVID-19. Patients aged ≥ 18 years with confirmed COVID-19 who were admitted to the ICU were included. The present study had two phases. The first phase was designed as a one-day point prevalence study, and demographic and clinical findings were evaluated. In the second phase, the 28-day mortality was evaluated. RESULTS: As of August 11, 2021, 921 patients were enrolled in the study. The mean age of the patients was 65.42 ± 16.74 years, and 48.6% (n = 448) were female. Among the critically ill patients with COVID-19, 52.6% (n = 484) were unvaccinated, 7.7% (n = 71) were incompletely vaccinated, and 39.8% (n = 366) were fully vaccinated. A subgroup analysis of 817 patients who were unvaccinated (n = 484) or who had received two doses of the CoronaVac vaccine (n = 333) was performed. The 28-day mortality rate was 56.8% (n = 275) and 57.4% (n = 191) in the unvaccinated and two-dose CoronaVac groups, respectively. The 28-day mortality was associated with age, hypertension, the number of comorbidities, type of respiratory support, and APACHE II and sequential organ failure assessment scores (p < 0.05). The odds ratio for the 28-day mortality among those who had received two doses of CoronaVac was 0.591 (95% confidence interval: 0.413-0.848) (p = 0.004). CONCLUSION: Vaccination with at least two doses of CoronaVac within six months significantly decreased mortality in vaccinated patients than in unvaccinated patients. |
| format | Online Article Text |
| id | pubmed-10613737 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Galenos Publishing |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-106137372023-10-31 The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye Gül, Fethi Kasapoğlu, Umut Sabri Sabaz, Mehmet Süleyman Ay, Pınar Doruk Oktay, Burçin Çalışkan, Gülbahar Demir, Nalan Sayan, İsmet Kabadayı, Feyyaz Altuntaş, Gülsüm Gümüş, Ayça Kırca, Hülya Şanlı, Deniz Acil, Fatma Dedeoğlu, Andaç Ural, Sedef Gülçin Akın Şen, İrem Macit Aydın, Eda Dayanır, Hakan Yelken, Birgül Ceylan, İlkay Aydın, Osman Özcan Eskidemir, Güneş Aytekin, Ahmet Cengiz, Melike Arslan, Ülkü Akdağ, Devrim Alay, Gülçin Hilal Tekin, Esra Yarar, Volkan Saracoğlu, Kemal Tolga Gök, Funda Alparslan, Volkan Tuna, Verda Yıldız, Murside Şenoğlu, Nimet Kıraklı, Cenk Yıldırım, Süleyman Saçar Kübüç, Kübra Erer, Ayşen Gültekin, Hamza Özmen Süner, Kezban Kuzgun, Özge Öztürk, Çağatay Erman Karahan, Aydın Deveci, Okan Ay, Mustafa Tüfek Öztan, Dilara Akıncı, Seda Banu Solak, Melahat Yalçın Bozbay, Süha Özçiftçi, Serhat Gönderen, Kamil Küçük, Ahmet Oğuzhan Uyan, Berna Elay, Gülseren Boyacı, Nazlıhan Timurkaan, Mustafa Karakoç, Ebru Doğan, Lerzan Yalçınkaya, Erdem Kazancıoğlu, Leyla Erdal Dönmez, Gül Yılmaz, Barış Ergül, Dursun Fırat Boran, Maruf Özkarakaş, Hüseyin Karakaş, Buğra Ergin Özcan, Perihan Anaklı, İlkay Bayar, Mustafa Kemal Yüksel, Didem Akdağ, Şükriye Pişkin, Özcan Temur, Sibel Eyüpoğlu, Selin Tekir Yılmaz, Elvan Avcı, Gizem Zaim Turan, Raziye Alkan Bayburt, Fatma Şahintürk, Helin Güçyetmez, Bülent Alparslan, Mustafa Muhlis Yarıcı, Metin Yıldırım, Fatma Yektaş, Abdulkadir Yaman, Güçlü Demirkıran, Oktay Cinel, İsmail Balkan Med J Original Article BACKGROUND: Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with COVID-19 remains unclear. AIMS: To determine the vaccination status and investigate the impact of the COVID-19 vaccine on the 28-day mortality in critically ill patients with COVID-19. STUDY DESIGN: Multicenter prospective observational clinical study. METHODS: This study was conducted in 60 hospitals with ICUs managing critically ill patients with COVID-19. Patients aged ≥ 18 years with confirmed COVID-19 who were admitted to the ICU were included. The present study had two phases. The first phase was designed as a one-day point prevalence study, and demographic and clinical findings were evaluated. In the second phase, the 28-day mortality was evaluated. RESULTS: As of August 11, 2021, 921 patients were enrolled in the study. The mean age of the patients was 65.42 ± 16.74 years, and 48.6% (n = 448) were female. Among the critically ill patients with COVID-19, 52.6% (n = 484) were unvaccinated, 7.7% (n = 71) were incompletely vaccinated, and 39.8% (n = 366) were fully vaccinated. A subgroup analysis of 817 patients who were unvaccinated (n = 484) or who had received two doses of the CoronaVac vaccine (n = 333) was performed. The 28-day mortality rate was 56.8% (n = 275) and 57.4% (n = 191) in the unvaccinated and two-dose CoronaVac groups, respectively. The 28-day mortality was associated with age, hypertension, the number of comorbidities, type of respiratory support, and APACHE II and sequential organ failure assessment scores (p < 0.05). The odds ratio for the 28-day mortality among those who had received two doses of CoronaVac was 0.591 (95% confidence interval: 0.413-0.848) (p = 0.004). CONCLUSION: Vaccination with at least two doses of CoronaVac within six months significantly decreased mortality in vaccinated patients than in unvaccinated patients. Galenos Publishing 2023-10-20 /pmc/articles/PMC10613737/ /pubmed/37867428 http://dx.doi.org/10.4274/balkanmedj.galenos.2023.2023-6-90 Text en ©Copyright 2023 by Trakya University Faculty of Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Balkan Medical Journal published by Galenos Publishing House. |
| spellingShingle | Original Article Gül, Fethi Kasapoğlu, Umut Sabri Sabaz, Mehmet Süleyman Ay, Pınar Doruk Oktay, Burçin Çalışkan, Gülbahar Demir, Nalan Sayan, İsmet Kabadayı, Feyyaz Altuntaş, Gülsüm Gümüş, Ayça Kırca, Hülya Şanlı, Deniz Acil, Fatma Dedeoğlu, Andaç Ural, Sedef Gülçin Akın Şen, İrem Macit Aydın, Eda Dayanır, Hakan Yelken, Birgül Ceylan, İlkay Aydın, Osman Özcan Eskidemir, Güneş Aytekin, Ahmet Cengiz, Melike Arslan, Ülkü Akdağ, Devrim Alay, Gülçin Hilal Tekin, Esra Yarar, Volkan Saracoğlu, Kemal Tolga Gök, Funda Alparslan, Volkan Tuna, Verda Yıldız, Murside Şenoğlu, Nimet Kıraklı, Cenk Yıldırım, Süleyman Saçar Kübüç, Kübra Erer, Ayşen Gültekin, Hamza Özmen Süner, Kezban Kuzgun, Özge Öztürk, Çağatay Erman Karahan, Aydın Deveci, Okan Ay, Mustafa Tüfek Öztan, Dilara Akıncı, Seda Banu Solak, Melahat Yalçın Bozbay, Süha Özçiftçi, Serhat Gönderen, Kamil Küçük, Ahmet Oğuzhan Uyan, Berna Elay, Gülseren Boyacı, Nazlıhan Timurkaan, Mustafa Karakoç, Ebru Doğan, Lerzan Yalçınkaya, Erdem Kazancıoğlu, Leyla Erdal Dönmez, Gül Yılmaz, Barış Ergül, Dursun Fırat Boran, Maruf Özkarakaş, Hüseyin Karakaş, Buğra Ergin Özcan, Perihan Anaklı, İlkay Bayar, Mustafa Kemal Yüksel, Didem Akdağ, Şükriye Pişkin, Özcan Temur, Sibel Eyüpoğlu, Selin Tekir Yılmaz, Elvan Avcı, Gizem Zaim Turan, Raziye Alkan Bayburt, Fatma Şahintürk, Helin Güçyetmez, Bülent Alparslan, Mustafa Muhlis Yarıcı, Metin Yıldırım, Fatma Yektaş, Abdulkadir Yaman, Güçlü Demirkıran, Oktay Cinel, İsmail The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye |
| title | The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye |
| title_full | The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye |
| title_fullStr | The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye |
| title_full_unstemmed | The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye |
| title_short | The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye |
| title_sort | impact of coronavac vaccination on 28-day mortality rate of critically ill patients with covid-19 in türkiye |
| topic | Original Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613737/ https://www.ncbi.nlm.nih.gov/pubmed/37867428 http://dx.doi.org/10.4274/balkanmedj.galenos.2023.2023-6-90 |
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theimpactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT turanraziye theimpactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT alkanbayburtfatma theimpactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT sahinturkhelin theimpactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT gucyetmezbulent theimpactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT alparslanmustafamuhlis theimpactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yarıcımetin theimpactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yıldırımfatma theimpactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yektasabdulkadir theimpactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yamanguclu theimpactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT demirkıranoktay theimpactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT cinelismail theimpactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT gulfethi impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT kasapogluumutsabri impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT sabazmehmetsuleyman impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT aypınar impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT dorukoktayburcin impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT calıskangulbahar impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT demirnalan impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT sayanismet impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT kabadayıfeyyaz impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT altuntasgulsum impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT gumusayca impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT kırcahulya impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT sanlıdeniz impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT acilfatma impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT dedeogluandac impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT uralsedefgulcin impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT akınsenirem impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT macitaydıneda impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT dayanırhakan impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yelkenbirgul impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT ceylanilkay impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT aydınosmanozcan impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT eskidemirgunes impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT aytekinahmet impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT cengizmelike impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT arslanulku impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT akdagdevrim impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT alaygulcinhilal impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT tekinesra impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yararvolkan impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT saracoglukemaltolga impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT gokfunda impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT alparslanvolkan impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT tunaverda impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yıldızmurside impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT senoglunimet impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT kıraklıcenk impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yıldırımsuleyman impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT sacarkubuckubra impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT ereraysen impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT gultekinhamza impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT ozmensunerkezban impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT kuzgunozge impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT ozturkcagatayerman impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT karahanaydın impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT deveciokan impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT aymustafa impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT tufekoztandilara impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT akıncısedabanu impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT solakmelahatyalcın impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT bozbaysuha impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT ozciftciserhat impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT gonderenkamil impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT kucukahmetoguzhan impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT uyanberna impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT elaygulseren impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT boyacınazlıhan impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT timurkaanmustafa impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT karakocebru impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT doganlerzan impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yalcınkayaerdem impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT kazancıogluleyla impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT erdaldonmezgul impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yılmazbarıs impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT erguldursunfırat impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT boranmaruf impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT ozkarakashuseyin impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT karakasbugra impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT erginozcanperihan impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT anaklıilkay impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT bayarmustafakemal impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yukseldidem impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT akdagsukriye impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT piskinozcan impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT temursibel impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT eyupogluselin impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT tekiryılmazelvan impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT avcıgizemzaim impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT turanraziye impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT alkanbayburtfatma impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT sahinturkhelin impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT gucyetmezbulent impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT alparslanmustafamuhlis impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yarıcımetin impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yıldırımfatma impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yektasabdulkadir impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT yamanguclu impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT demirkıranoktay impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye AT cinelismail impactofcoronavacvaccinationon28daymortalityrateofcriticallyillpatientswithcovid19inturkiye |