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Revolutionizing Heart Transplantation: A Multidisciplinary Approach to Xenotransplantation, Immunosuppression, Regenerative Medicine, Artificial Intelligence, and Economic Sustainability

Heart transplantation (HTx) stands as a life-saving intervention for patients with end-stage heart disease, but the field is fraught with numerous challenges that span from the scarcity of donor organs to long-term complications arising from immunosuppressive therapies. This comprehensive review art...

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Autores principales: Tanveer, Yousaf, Arif, Aleena, Tsenteradze, Tamar, Anika, Nabila N, Bakht, Danyal, Masood, Quratulain Fatima, Affaf, Maryam, Batool, Wajiha, Yadav, Indresh, Gasim, Rayan W, Mohamed, Youssef, Abdelmonim Khogali Mohamed, Mohamed, Ekhator, Chukwuyem, Mohsin, Syed Naveed, Khan, Rehman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613786/
https://www.ncbi.nlm.nih.gov/pubmed/37908951
http://dx.doi.org/10.7759/cureus.46176
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author Tanveer, Yousaf
Arif, Aleena
Tsenteradze, Tamar
Anika, Nabila N
Bakht, Danyal
Masood, Quratulain Fatima
Affaf, Maryam
Batool, Wajiha
Yadav, Indresh
Gasim, Rayan W
Mohamed, Youssef
Abdelmonim Khogali Mohamed, Mohamed
Ekhator, Chukwuyem
Mohsin, Syed Naveed
Khan, Rehman
author_facet Tanveer, Yousaf
Arif, Aleena
Tsenteradze, Tamar
Anika, Nabila N
Bakht, Danyal
Masood, Quratulain Fatima
Affaf, Maryam
Batool, Wajiha
Yadav, Indresh
Gasim, Rayan W
Mohamed, Youssef
Abdelmonim Khogali Mohamed, Mohamed
Ekhator, Chukwuyem
Mohsin, Syed Naveed
Khan, Rehman
author_sort Tanveer, Yousaf
collection PubMed
description Heart transplantation (HTx) stands as a life-saving intervention for patients with end-stage heart disease, but the field is fraught with numerous challenges that span from the scarcity of donor organs to long-term complications arising from immunosuppressive therapies. This comprehensive review article offers an in-depth exploration of the multifaceted aspects of HTx. The review covers groundbreaking advancements in xenotransplantation, enabled by cutting-edge genetic engineering techniques, and the promising role of stem cell therapies, particularly porcine mesenchymal stem cells, in cardiac regeneration. It also delves into the evolution and limitations of immunosuppressive therapies and the revolutionary potential of artificial intelligence (AI) and machine learning (ML) in enhancing donor-recipient matching and predicting patient outcomes. Economic considerations, especially in the context of rising healthcare costs, are examined to assess the sustainability of these advancements. The article further discusses the significant improvements in patient outcomes over the years, while highlighting persisting challenges, such as graft failure, rejection, and infection. It underscores the importance of experience and specialized training, evidenced by the presence of an institutional learning curve. The review concludes by advocating for a multifaceted, collaborative approach involving clinicians, researchers, and policymakers to overcome existing challenges. Through coordinated efforts that consider medical, ethical, and economic factors, the field of HTx is poised for further evolution, offering renewed hope for improved patient care and outcomes.
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spelling pubmed-106137862023-10-31 Revolutionizing Heart Transplantation: A Multidisciplinary Approach to Xenotransplantation, Immunosuppression, Regenerative Medicine, Artificial Intelligence, and Economic Sustainability Tanveer, Yousaf Arif, Aleena Tsenteradze, Tamar Anika, Nabila N Bakht, Danyal Masood, Quratulain Fatima Affaf, Maryam Batool, Wajiha Yadav, Indresh Gasim, Rayan W Mohamed, Youssef Abdelmonim Khogali Mohamed, Mohamed Ekhator, Chukwuyem Mohsin, Syed Naveed Khan, Rehman Cureus Internal Medicine Heart transplantation (HTx) stands as a life-saving intervention for patients with end-stage heart disease, but the field is fraught with numerous challenges that span from the scarcity of donor organs to long-term complications arising from immunosuppressive therapies. This comprehensive review article offers an in-depth exploration of the multifaceted aspects of HTx. The review covers groundbreaking advancements in xenotransplantation, enabled by cutting-edge genetic engineering techniques, and the promising role of stem cell therapies, particularly porcine mesenchymal stem cells, in cardiac regeneration. It also delves into the evolution and limitations of immunosuppressive therapies and the revolutionary potential of artificial intelligence (AI) and machine learning (ML) in enhancing donor-recipient matching and predicting patient outcomes. Economic considerations, especially in the context of rising healthcare costs, are examined to assess the sustainability of these advancements. The article further discusses the significant improvements in patient outcomes over the years, while highlighting persisting challenges, such as graft failure, rejection, and infection. It underscores the importance of experience and specialized training, evidenced by the presence of an institutional learning curve. The review concludes by advocating for a multifaceted, collaborative approach involving clinicians, researchers, and policymakers to overcome existing challenges. Through coordinated efforts that consider medical, ethical, and economic factors, the field of HTx is poised for further evolution, offering renewed hope for improved patient care and outcomes. Cureus 2023-09-29 /pmc/articles/PMC10613786/ /pubmed/37908951 http://dx.doi.org/10.7759/cureus.46176 Text en Copyright © 2023, Tanveer et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Tanveer, Yousaf
Arif, Aleena
Tsenteradze, Tamar
Anika, Nabila N
Bakht, Danyal
Masood, Quratulain Fatima
Affaf, Maryam
Batool, Wajiha
Yadav, Indresh
Gasim, Rayan W
Mohamed, Youssef
Abdelmonim Khogali Mohamed, Mohamed
Ekhator, Chukwuyem
Mohsin, Syed Naveed
Khan, Rehman
Revolutionizing Heart Transplantation: A Multidisciplinary Approach to Xenotransplantation, Immunosuppression, Regenerative Medicine, Artificial Intelligence, and Economic Sustainability
title Revolutionizing Heart Transplantation: A Multidisciplinary Approach to Xenotransplantation, Immunosuppression, Regenerative Medicine, Artificial Intelligence, and Economic Sustainability
title_full Revolutionizing Heart Transplantation: A Multidisciplinary Approach to Xenotransplantation, Immunosuppression, Regenerative Medicine, Artificial Intelligence, and Economic Sustainability
title_fullStr Revolutionizing Heart Transplantation: A Multidisciplinary Approach to Xenotransplantation, Immunosuppression, Regenerative Medicine, Artificial Intelligence, and Economic Sustainability
title_full_unstemmed Revolutionizing Heart Transplantation: A Multidisciplinary Approach to Xenotransplantation, Immunosuppression, Regenerative Medicine, Artificial Intelligence, and Economic Sustainability
title_short Revolutionizing Heart Transplantation: A Multidisciplinary Approach to Xenotransplantation, Immunosuppression, Regenerative Medicine, Artificial Intelligence, and Economic Sustainability
title_sort revolutionizing heart transplantation: a multidisciplinary approach to xenotransplantation, immunosuppression, regenerative medicine, artificial intelligence, and economic sustainability
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613786/
https://www.ncbi.nlm.nih.gov/pubmed/37908951
http://dx.doi.org/10.7759/cureus.46176
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