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SET-CAN/NUP214 fusion gene in leukemia: general features and clinical advances
SET-CAN/NUP214 fusion is a recurrent event commonly observed in adult male patients diagnosed with T-cell acute lymphoblastic leukemia (T-ALL) and has occasionally been reported in other diseases such as acute myeloid leukemia (AML), myeloid sarcoma (MS), acute undifferentiated leukemia (AUL), chron...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613893/ https://www.ncbi.nlm.nih.gov/pubmed/37909026 http://dx.doi.org/10.3389/fonc.2023.1269531 |
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author | Song, Jingyu Li, Huibo Fan, Shengjin |
author_facet | Song, Jingyu Li, Huibo Fan, Shengjin |
author_sort | Song, Jingyu |
collection | PubMed |
description | SET-CAN/NUP214 fusion is a recurrent event commonly observed in adult male patients diagnosed with T-cell acute lymphoblastic leukemia (T-ALL) and has occasionally been reported in other diseases such as acute myeloid leukemia (AML), myeloid sarcoma (MS), acute undifferentiated leukemia (AUL), chronic myeloid leukemia (CML) and B-cell acute lymphoblastic leukemia (B-ALL). This fusion gene is derived from chromosome del(9)(q34.11;q34.13) or t(9;9)(q34;q34) and may have an inhibitory effect on primitive progenitor differentiation. The prognosis of the reported patients is varied, with these patients often show resistance to chemotherapy regimens that include high doses of glucocorticoids. The optional treatment has not been determined, more cases need to be accumulated and evaluated. The scope of this review is to summarize the general features and prognostic significance in leukemia associated with the SET-CAN/NUP214 fusion gene and to discuss the methods of detection and treatment, aiming at providing some useful references for relevant researchers in the field of blood tumor. |
format | Online Article Text |
id | pubmed-10613893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106138932023-10-31 SET-CAN/NUP214 fusion gene in leukemia: general features and clinical advances Song, Jingyu Li, Huibo Fan, Shengjin Front Oncol Oncology SET-CAN/NUP214 fusion is a recurrent event commonly observed in adult male patients diagnosed with T-cell acute lymphoblastic leukemia (T-ALL) and has occasionally been reported in other diseases such as acute myeloid leukemia (AML), myeloid sarcoma (MS), acute undifferentiated leukemia (AUL), chronic myeloid leukemia (CML) and B-cell acute lymphoblastic leukemia (B-ALL). This fusion gene is derived from chromosome del(9)(q34.11;q34.13) or t(9;9)(q34;q34) and may have an inhibitory effect on primitive progenitor differentiation. The prognosis of the reported patients is varied, with these patients often show resistance to chemotherapy regimens that include high doses of glucocorticoids. The optional treatment has not been determined, more cases need to be accumulated and evaluated. The scope of this review is to summarize the general features and prognostic significance in leukemia associated with the SET-CAN/NUP214 fusion gene and to discuss the methods of detection and treatment, aiming at providing some useful references for relevant researchers in the field of blood tumor. Frontiers Media S.A. 2023-10-16 /pmc/articles/PMC10613893/ /pubmed/37909026 http://dx.doi.org/10.3389/fonc.2023.1269531 Text en Copyright © 2023 Song, Li and Fan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Song, Jingyu Li, Huibo Fan, Shengjin SET-CAN/NUP214 fusion gene in leukemia: general features and clinical advances |
title | SET-CAN/NUP214 fusion gene in leukemia: general features and clinical advances |
title_full | SET-CAN/NUP214 fusion gene in leukemia: general features and clinical advances |
title_fullStr | SET-CAN/NUP214 fusion gene in leukemia: general features and clinical advances |
title_full_unstemmed | SET-CAN/NUP214 fusion gene in leukemia: general features and clinical advances |
title_short | SET-CAN/NUP214 fusion gene in leukemia: general features and clinical advances |
title_sort | set-can/nup214 fusion gene in leukemia: general features and clinical advances |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613893/ https://www.ncbi.nlm.nih.gov/pubmed/37909026 http://dx.doi.org/10.3389/fonc.2023.1269531 |
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