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Exploring pharmacokinetics of talazoparib in ABCB1/ABCG2-deficient mice using a novel UHPLC-MS/MS method

A rapid, sensitive, and simple UHPLC-MS/MS method for the determination of the PARP inhibitor talazoparib in mouse plasma was developed and validated using [(13)C,(2)H(4)]-talazoparib as an internal standard (IS). The assay procedure involved extraction of talazoparib and the IS from plasma using a...

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Detalles Bibliográficos
Autores principales:	Talebi, Zahra, Garrison, Dominique A., Eisenmann, Eric D., Parmar, Kalindi, Shapiro, Geoffrey I., Rudek, Michelle A., Sparreboom, Alex, Jin, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613910/ https://www.ncbi.nlm.nih.gov/pubmed/37908705 http://dx.doi.org/10.1016/j.heliyon.2023.e20972

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