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Case Report: Immune dysregulation associated with long-lasting regression of a (pre)leukemic clone

Regression of leukemia in the absence of disease-modifying therapy remains poorly understood, although immunological mechanisms are thought to play a role. Here, we present a unique case of a 17-year-old boy with immune dysregulation and long-lasting regression of a (pre)leukemic clone in the absenc...

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Autores principales: Koedijk, Joost B., van Beek, Thomas B., Vermeulen, Marijn A., Kester, Lennart A., Schweighart, Elizabeth K., Nierkens, Stefan, Belderbos, Mirjam E., Zwaan, C. Michel, Heitink-Pollé, Katja M. J., Heidenreich, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613973/
https://www.ncbi.nlm.nih.gov/pubmed/37908360
http://dx.doi.org/10.3389/fimmu.2023.1280885
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author Koedijk, Joost B.
van Beek, Thomas B.
Vermeulen, Marijn A.
Kester, Lennart A.
Schweighart, Elizabeth K.
Nierkens, Stefan
Belderbos, Mirjam E.
Zwaan, C. Michel
Heitink-Pollé, Katja M. J.
Heidenreich, Olaf
author_facet Koedijk, Joost B.
van Beek, Thomas B.
Vermeulen, Marijn A.
Kester, Lennart A.
Schweighart, Elizabeth K.
Nierkens, Stefan
Belderbos, Mirjam E.
Zwaan, C. Michel
Heitink-Pollé, Katja M. J.
Heidenreich, Olaf
author_sort Koedijk, Joost B.
collection PubMed
description Regression of leukemia in the absence of disease-modifying therapy remains poorly understood, although immunological mechanisms are thought to play a role. Here, we present a unique case of a 17-year-old boy with immune dysregulation and long-lasting regression of a (pre)leukemic clone in the absence of disease-modifying therapy. Using molecular and immunological analyses, we identified bone marrow features associated with disease control and loss thereof. In addition, our case reveals that detection of certain fusion genes with hardly any blasts in the bone marrow may be indicative of an accompanying oncogenic fusion gene, with implications for disease surveillance- and management in future patients.
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spelling pubmed-106139732023-10-31 Case Report: Immune dysregulation associated with long-lasting regression of a (pre)leukemic clone Koedijk, Joost B. van Beek, Thomas B. Vermeulen, Marijn A. Kester, Lennart A. Schweighart, Elizabeth K. Nierkens, Stefan Belderbos, Mirjam E. Zwaan, C. Michel Heitink-Pollé, Katja M. J. Heidenreich, Olaf Front Immunol Immunology Regression of leukemia in the absence of disease-modifying therapy remains poorly understood, although immunological mechanisms are thought to play a role. Here, we present a unique case of a 17-year-old boy with immune dysregulation and long-lasting regression of a (pre)leukemic clone in the absence of disease-modifying therapy. Using molecular and immunological analyses, we identified bone marrow features associated with disease control and loss thereof. In addition, our case reveals that detection of certain fusion genes with hardly any blasts in the bone marrow may be indicative of an accompanying oncogenic fusion gene, with implications for disease surveillance- and management in future patients. Frontiers Media S.A. 2023-10-16 /pmc/articles/PMC10613973/ /pubmed/37908360 http://dx.doi.org/10.3389/fimmu.2023.1280885 Text en Copyright © 2023 Koedijk, van Beek, Vermeulen, Kester, Schweighart, Nierkens, Belderbos, Zwaan, Heitink-Pollé and Heidenreich https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Koedijk, Joost B.
van Beek, Thomas B.
Vermeulen, Marijn A.
Kester, Lennart A.
Schweighart, Elizabeth K.
Nierkens, Stefan
Belderbos, Mirjam E.
Zwaan, C. Michel
Heitink-Pollé, Katja M. J.
Heidenreich, Olaf
Case Report: Immune dysregulation associated with long-lasting regression of a (pre)leukemic clone
title Case Report: Immune dysregulation associated with long-lasting regression of a (pre)leukemic clone
title_full Case Report: Immune dysregulation associated with long-lasting regression of a (pre)leukemic clone
title_fullStr Case Report: Immune dysregulation associated with long-lasting regression of a (pre)leukemic clone
title_full_unstemmed Case Report: Immune dysregulation associated with long-lasting regression of a (pre)leukemic clone
title_short Case Report: Immune dysregulation associated with long-lasting regression of a (pre)leukemic clone
title_sort case report: immune dysregulation associated with long-lasting regression of a (pre)leukemic clone
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613973/
https://www.ncbi.nlm.nih.gov/pubmed/37908360
http://dx.doi.org/10.3389/fimmu.2023.1280885
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