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Angioedema From Triple Therapy: A Case Report

Angioedema is a rare but potentially life-threatening complication associated with angiotensin-converting enzyme (ACE) inhibitors. Although the pathophysiology is well understood, cases involving the concurrent use of other medications are less explored. We present a unique case of ACE inhibitor-ind...

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Autores principales: Lepore, Nicholas, Carpenter, Taya, Wolff, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614077/
https://www.ncbi.nlm.nih.gov/pubmed/37908932
http://dx.doi.org/10.7759/cureus.46247
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author Lepore, Nicholas
Carpenter, Taya
Wolff, Alan
author_facet Lepore, Nicholas
Carpenter, Taya
Wolff, Alan
author_sort Lepore, Nicholas
collection PubMed
description Angioedema is a rare but potentially life-threatening complication associated with angiotensin-converting enzyme (ACE) inhibitors. Although the pathophysiology is well understood, cases involving the concurrent use of other medications are less explored. We present a unique case of ACE inhibitor-induced angioedema in a 57-year-old male, which developed soon after receiving intravenous contrast. The patient's medication list included a dipeptidyl peptidase-IV inhibitor and a calcium channel blocker. Studies have shown an increased risk of angioedema with the combined use of these medications, likely due to alterations in bradykinin metabolism. This case highlights the importance of medication review and consideration of potential drug interactions when prescribing ACE inhibitors. It emphasizes the significance of diagnostic accuracy to avoid the mislabeling of allergies and consideration of other etiologies in angioedema. Healthcare providers ought to be mindful of the increased risk of angioedema when prescribing dipeptidyl peptidase-IV inhibitors and calcium-channel blockers with ACE inhibitors, as these are frequently used medications.
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spelling pubmed-106140772023-10-31 Angioedema From Triple Therapy: A Case Report Lepore, Nicholas Carpenter, Taya Wolff, Alan Cureus Internal Medicine Angioedema is a rare but potentially life-threatening complication associated with angiotensin-converting enzyme (ACE) inhibitors. Although the pathophysiology is well understood, cases involving the concurrent use of other medications are less explored. We present a unique case of ACE inhibitor-induced angioedema in a 57-year-old male, which developed soon after receiving intravenous contrast. The patient's medication list included a dipeptidyl peptidase-IV inhibitor and a calcium channel blocker. Studies have shown an increased risk of angioedema with the combined use of these medications, likely due to alterations in bradykinin metabolism. This case highlights the importance of medication review and consideration of potential drug interactions when prescribing ACE inhibitors. It emphasizes the significance of diagnostic accuracy to avoid the mislabeling of allergies and consideration of other etiologies in angioedema. Healthcare providers ought to be mindful of the increased risk of angioedema when prescribing dipeptidyl peptidase-IV inhibitors and calcium-channel blockers with ACE inhibitors, as these are frequently used medications. Cureus 2023-09-30 /pmc/articles/PMC10614077/ /pubmed/37908932 http://dx.doi.org/10.7759/cureus.46247 Text en Copyright © 2023, Lepore et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Lepore, Nicholas
Carpenter, Taya
Wolff, Alan
Angioedema From Triple Therapy: A Case Report
title Angioedema From Triple Therapy: A Case Report
title_full Angioedema From Triple Therapy: A Case Report
title_fullStr Angioedema From Triple Therapy: A Case Report
title_full_unstemmed Angioedema From Triple Therapy: A Case Report
title_short Angioedema From Triple Therapy: A Case Report
title_sort angioedema from triple therapy: a case report
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614077/
https://www.ncbi.nlm.nih.gov/pubmed/37908932
http://dx.doi.org/10.7759/cureus.46247
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